Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.
Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons
It is shown that selective expression of the proton-activated receptor GPR4 in chemosensory neurons of the mouse retrotrapezoid nucleus (RTN) is required for CO2-stimulated breathing, and the data identify G PR4 and TASK-2 as distinct, parallel, and essential central mediators of respiratory chemosensitivity.
S-Nitrosylation Inhibits Pannexin 1 Channel Function*
The results provide the first evidence of a reversible post-translational modification on pannexin 1 to regulate channel activity and indicate that S-nitrosylation of Panx1 at Cys-40 and CYS-346 inhibits channel currents and ATP release.
Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation.
Hematopoietic pannexin 1 function is critical for neuropathic pain
It is shown that Pannexin 1 in hematopoietic cells is required for pain-like responses following nerve injury in mice, and inhibition of Panx1 may be useful in treating neuropathic pain, and a potential therapeutic target is suggested.
Nalcn Is a “Leak” Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing
It is shown that a leak Na+ channel, Nalcn, is expressed in the CO2/H+-sensitive neurons of the mouse retrotrapezoid nucleus (RTN) that regulate breathing, and a specific function for this enigmatic channel is defined in an important physiological context.
Channel Function -Nitrosylation Inhibits Pannexin 1 S Membrane Biology:
Complex interplay between Pannexin 1 cysteine residues and channel regulation
Functional effects of Panx1 S‐nitrosylation are assessed and a complex interplay between cysteine regulation of pore function and NO is suggested.