Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.
- B. M. Kenwood, Janelle L Weaver, K. Hoehn
- Biology, ChemistryMolecular Metabolism
- 1 April 2014
Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons
- Natasha N. Kumar, A. Velic, D. Bayliss
- BiologyScience
- 12 June 2015
It is shown that selective expression of the proton-activated receptor GPR4 in chemosensory neurons of the mouse retrotrapezoid nucleus (RTN) is required for CO2-stimulated breathing, and the data identify G PR4 and TASK-2 as distinct, parallel, and essential central mediators of respiratory chemosensitivity.
S-Nitrosylation Inhibits Pannexin 1 Channel Function*
- A. Lohman, Janelle L Weaver, B. Isakson
- BiologyJournal of Biological Chemistry
- 2 October 2012
The results provide the first evidence of a reversible post-translational modification on pannexin 1 to regulate channel activity and indicate that S-nitrosylation of Panx1 at Cys-40 and CYS-346 inhibits channel currents and ATP release.
Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation.
- C. Morenilla-Palao, E. Luis, F. Viana
- BiologyCell Reports
- 11 September 2014
Hematopoietic pannexin 1 function is critical for neuropathic pain
- Janelle L Weaver, S. Arandjelovic, D. Bayliss
- Biology, MedicineScientific Reports
- 14 February 2017
It is shown that Pannexin 1 in hematopoietic cells is required for pain-like responses following nerve injury in mice, and inhibition of Panx1 may be useful in treating neuropathic pain, and a potential therapeutic target is suggested.
Nalcn Is a “Leak” Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing
- Yingtang Shi, Chikara Abe, D. Bayliss
- BiologyJournal of Neuroscience
- 3 August 2016
It is shown that a leak Na+ channel, Nalcn, is expressed in the CO2/H+-sensitive neurons of the mouse retrotrapezoid nucleus (RTN) that regulate breathing, and a specific function for this enigmatic channel is defined in an important physiological context.
Channel Function -Nitrosylation Inhibits Pannexin 1 S Membrane Biology:
- N. Leitinger, D. Laird, Janelle L Weaver
- Biology
- 2014
Complex interplay between Pannexin 1 cysteine residues and channel regulation
- A. Lohman, Janelle L Weaver, M. Billaud, D. Bayliss, B. Isakson
- Biology
- 1 April 2012
Functional effects of Panx1 S‐nitrosylation are assessed and a complex interplay between cysteine regulation of pore function and NO is suggested.