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Unified Huntington's disease rating scale: Reliability and consistency
- K. Kieburtz, J. Penney, V. Hunt
- Psychology, MedicineMovement disorders : official journal of the…
- 1 March 1996
The limited longitudinal database indicates that the UHDRS may be useful for tracking changes in the clinical features of HD over time and there was an excellent degree of interrater reliability for the motor scores.
Detection of Huntington’s disease decades before diagnosis: the Predict-HD study
- Jane S. Paulsen, D. Langbehn, M. Hayden
- Medicine, PsychologyJournal of Neurology, Neurosurgery, and…
- 20 December 2007
The findings from the Predict-HD study suggest the approximate time scale of measurable disease development, and suggest candidate disease markers for use in preventive HD trials.
A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length
A parametric survival model based on CAG repeat length is developed to predict the probability of neurological disease onset (based on motor neurological symptoms rather than psychiatric onset) at different ages for individual patients using the largest cohort of HD patients analyzed to date.
Huntington disease: natural history, biomarkers and prospects for therapeutics
The natural history of HD is described, including the timing of emergence of motor, cognitive and emotional impairments, and the techniques that are used to assess these features, and potential future roles of these biomarkers in clinical trials are reviewed.
Memory in the Cerebral Cortex: An Empirical Approach to Neural Networks in the Human and Nonhuman Primate
- Jane S. Paulsen
- 1 November 1996
Is it possible to be schizophrenic yet neuropsychologically normal?
The existence of NP-normal schizophrenics suggests that the pathophysiology underlying the cognitive deficits often associated with schizophrenia may be distinct from that causing some of its core psychiatric features.
Apathy is not depression.
- M. Levy, J. Cummings, I. Litvan
- Psychology, MedicineThe Journal of neuropsychiatry and clinical…
- 1 August 1998
If depression is associated with apathy, then they should be expressed together in different dementia syndromes and should co-occur at varying levels of disease severity. The authors performed a…
Classifying neurocognitive disorders: the DSM-5 approach
The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) provides a common framework for the diagnosis of neuroc cognitive disorders, first by describing the main cognitive syndromes, and then defining criteria to delineate specific aetiological subtypes of mild and major neurocognitive disorders.
Neuropsychiatric aspects of Huntington's disease
- Jane S. Paulsen, R. Ready, J. Hamilton, M. Mega, J. Cummings
- Psychology, MedicineJournal of neurology, neurosurgery, and…
- 1 September 2001
Findings indicate that dimensional measures of neuropsychiatric symptoms are essential to capture the full range of pathology in Huntington's disease and are vital to include in a comprehensive assessment of the disease.