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Cell line‐specific control of recombinant monoclonal antibody production by CHO cells
TLDR
It is shown that cell lines capable of high qMab exceed a threshold functional competency in all synthetic processes, and the majority of cells in parental and transfected cell populations are functionally limited and cell engineering strategies to increase Mab production should be cell line specific.
An empirical modeling platform to evaluate the relative control discrete CHO cell synthetic processes exert over recombinant monoclonal antibody production process titer
TLDR
This study shows that application of this whole‐process predictive modeling strategy should rationally precede and inform cell engineering approaches to increase production of a recombinant protein by a mammalian host cell—where control of productivity is inherently protein product and cell line specific.
Impact of gene vector design on the control of recombinant monoclonal antibody production by chinese hamster ovary cells
In this study, we systematically compare two vector design strategies for recombinant monoclonal antibody (Mab) synthesis by Chinese hamster ovary (CHO) cells; a dual open reading frame (ORF)
γ‐Secretase‐dependent cleavage of amyloid precursor protein regulates osteoblast behavior
TLDR
It is suggested that the mechanisms underlying the pathogenesis of AD may also influence bone and γ‐secretase‐dependent cleavage of amyloid precursor protein regulates osteoblast behavior.
Engineering Protein Folding and Secretion in Eukaryotic Cell Factories
TLDR
Cellular engineering strategies devised to overcome limitations within the cell factory are discussed, and novel approaches to implement control over product flux within thecell are described.