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Cell line‐specific control of recombinant monoclonal antibody production by CHO cells
In this study we compare the cellular control of recombinant human IgG4 monoclonal antibody (Mab) synthesis in different CHO cell lines. Based on comprehensive empirical analyses of mRNA andExpand
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An empirical modeling platform to evaluate the relative control discrete CHO cell synthetic processes exert over recombinant monoclonal antibody production process titer
In this study we have combined empirically derived mathematical models of intracellular Mab synthesis to quantitatively compare the degree to which individual cellular processes limit recombinantExpand
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Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial
Summary Background Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardialExpand
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Impact of gene vector design on the control of recombinant monoclonal antibody production by chinese hamster ovary cells
In this study, we systematically compare two vector design strategies for recombinant monoclonal antibody (Mab) synthesis by Chinese hamster ovary (CHO) cells; a dual open reading frame (ORF)Expand
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Engineering Protein Folding and Secretion in Eukaryotic Cell Factories
The past two decades have seen a rapid growth in the biopharmaceutical market. Underpinning this is a vast increase in the productivity of eukaryotic expression systems, with cellular engineeringExpand
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Quality assessment of online hepatocellular carcinoma patient education materials.
e24184Background: Hepatocellular carcinoma (HCC) is the fourth-leading cause of cancer-associated death in the world, claiming nearly 800,000 lives each year globally. Concurrently, an increasing n...
Quality Analysis of Online Patient Resources for Hepatocellular Carcinoma.
GOAL This study aims to evaluate the quality of online hepatocellular carcinoma (primary liver cancer) resources by using a validated tool to determine the strengths and limitations of hepatocellularExpand
Petitioning the King: The Case of Provincial Printers in Eighteenth-Century France
This essay studies an argumentative practice in eighteenth-century France by exploring the persuasiveness of some petitions to obtain printer licences. Those who wanted to enter the printing businessExpand
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Reflections and best practice recommendations for interdisciplinary working: a case study on the identification of the determinants of addiction from the Addiction and Lifestyles In Contemporary
Abstract Background Studies on the determinants of the development of substance use disorders are done across the natural and social sciences. However, research is usually conducted by individual orExpand
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