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It has been proposed that the positioning of mobile cells within a tissue is determined by their overall profile of chemokine receptors. This study examines the profiles of chemokine receptors expressed on resting and activated adult human microglial cells, astrocytes and a microglial cell line, CHME3. Microglia express highest levels of CXCR1, CXCR3 and(More)
GTP hydrolysis occurs at several specific stages during the initiation, elongation, and termination stages of mRNA translation. However, it is unclear how GTP hydrolysis occurs; it has previously been suggested to involve a GTPase active center in the ribosome, although proof for this is lacking. Alternatively, it could involve the translation factors(More)
In the present study, we report in two non related pediatric patients a primary immunodeficiency phenotype associated with a missense mutation in the moesin gene. The disease was characterized by T, B and NK lymphopenia and neutropenia. Both patients developed severe varicella complicated by bilateral pneumopathies and recurrent pulmonary infections until(More)
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