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[1] We use the GEOS-Chem chemical transport model to interpret observations of tropospheric ozone from the Tropospheric Emission Spectrometer (TES) satellite instrument in summer 2005. Observations from TES reveal elevated ozone in the middle troposphere (500–400 hPa) across North Africa and the Middle East. Observed ozone abundances in the middle(More)
Tissue engineering strategies for intervertebral disc repair have focused on the use of autologous disc-derived chondrocytes. Difficulties with graft procurement, harvest site morbidity, and functionality, however, may limit the utility of this cell source. We used an in vivo porcine model to investigate allogeneic non-disc-derived chondrocytes and(More)
STUDY DESIGN The degenerative response of rat tail and lumbar intervertebral discs to a stab incision was evaluated. OBJECTIVE To examine and compare the postinjury degenerative response of lumbar and tail discs. SUMMARY OF BACKGROUND DATA Although successful in larger animals, a stab incision for inducing disc degeneration in rats has not been(More)
BACKGROUND CONTEXT Discectomy is a surgical technique commonly used to treat bulging or herniated discs causing nerve root compression. Clinical data suggest discectomy may also help patients with contained discs and no clear neural compromise. However, the mechanisms of clinical efficacy are uncertain, and consequently bases for treatment optimization are(More)
STUDY DESIGN Surgically denucleated porcine intervertebral discs (IVD) were injected with BIOSTAT BIOLOGX Fibrin Sealant (FS), and the in vivo effects were assessed over time by histological, biochemical, and mechanical criteria. OBJECTIVE The objectives were to test whether the intradiscal injection of FS stimulates disc healing. SUMMARY OF BACKGROUND(More)
[1] We characterize the horizontal and vertical distribution of tropospheric ozone measured by the Tropospheric Emission Spectrometer (TES) over North Africa, the Middle East, and Asia. Studies have shown that the summertime circulation associated with the Asian monsoon significantly influences the spatial distribution of ozone and its precursors. However,(More)
Intervertebral disc (IVD) degeneration is a complex process characterized by elevated concentrations of proinflammatory cytokines and proteolytic enzymes. Because of pro-healing constituents, we hypothesized that fibrin sealant (FS) can reduce inflammation and augment soft tissue healing within the damaged or degenerative IVD. To test this, human and(More)
BACKGROUND CONTEXT Plasma-mediated radiofrequency-based ablation (coblation) is an electrosurgical technique currently used for tissue removal in a wide range of surgical applications, including lumbar microdiscectomy. In vitro and in vivo studies have shown the technique to alter the expression of inflammatory cytokines in the disc, increasing the levels(More)
Degenerative disc disease (DDD) is a common disabling condition for millions of individuals. Injection of xenogenic juvenile chondrocytes (XJC) into the disc space has been shown to have a therapeutic potential for disc repair. In the current study, XJC were injected extra-discally on neural structures in an in vivo rat hemilaminectomy model to compare the(More)
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