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Reward-seeking behavior depends critically on processing of positive and negative information at various stages such as reward anticipation, outcome monitoring, and choice evaluation. Behavioral and neuropsychological evidence suggests that processing of positive (e.g., gain) and negative (e.g., loss) reward information may be dissociable and individually(More)
BACKGROUND It has been hypothesised that seizure induced neuronal loss and axonal damage in medial temporal lobe epilepsy (MTLE) may lead to the development of aberrant connections between limbic structures and eventually result in the reorganisation of the limbic network. In this study, limbic structural connectivity in patients with MTLE was investigated,(More)
Information on normal functional organization and development of the ventral processing stream in 5- to 11-year-old children is minimal. The present fMRI study identified neural correlates for face and object processing in children aged 5-8 and 9-11 years, with data from a similar adult study used for comparison. All age groups showed face-preferential(More)
Face processing undergoes a fairly protracted developmental time course but the neural underpinnings are not well understood. Prior fMRI studies have only examined progressive changes (i.e., increases in specialization in certain regions with age), which would be predicted by both the Interactive Specialization (IS) and maturational theories of neural(More)
  • J E Joseph
  • 2001
Functional neuroimaging studies in which the cortical organization for semantic knowledge has been addressed have revealed interesting dissociations in the recognition of different object categories, such as faces, natural objects, and manufactured objects. The present paper critically reviews these studies and performs a meta-analysis of stereotactic(More)
Human occipitotemporal cortex (OTC) is critically involved in object recognition, but the functional organization of this brain region is controversial. In the present study, functional magnetic resonance imaging (fMRI) signal changes were recorded in humans during an animal-matching task that parametrically varied degree of structural (i.e., shape)(More)
We explored developmental changes in neural substrates for face processing, using fMRI. Children and adults performed a perceptual-matching task with upright and inverted face and animal stimuli. Behaviorally, inversion disrupted face processing more than animal processing for adults and older children. In line with this behavioral pattern, the left middle(More)
High sensation seeking has been linked to increased risk for drug abuse and other negative behavioral outcomes. This study explored the neurobiological basis of this personality trait using functional magnetic resonance imaging (fMRI). High sensation seekers (HSSs) and low sensation seekers (LSSs) viewed high- and low-arousal pictures. Comparison of the(More)
Although established adult smokers with long histories of nicotine dependence have lower neural tissue volume than non-smokers, it is not clear if lower regional brain volume is also observed in younger, less established smokers. The primary goal of this study was to investigate neural tissue volume in a large group of smokers and non-smokers, with a(More)
The present study determined the extent to which object and letter recognition recruit similar or dissociated neural resources. Participants passively viewed and silently named line drawings of objects, single letters, and visual noise patterns and centrally fixated an asterisk. We used whole-brain functional MRI and a very conservative approach to(More)