Jane Cheeseman

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OBJECTIVE Pharmacological use of peroxisome proliferator-activated receptor (PPAR)delta agonists and transgenic overexpression of PPARdelta in mice suggest amelioration of features of the metabolic(More)
RESEARCH DESIGN AND METHODS—The PPAR agonist (10 mg o.d. GW501516), a comparator PPAR agonist (20 g o.d. GW590735), and placebo were given in a double-blind, randomized, three-parallel group, 2-week(More)
The absolute configuration (AC) of a chiral molecule can be determined via calculation of its specific rotation. Currently, the latter is most accurately carried out using the TDDFT/GIAO methodology.(More)
[reaction: see text] The Baeyer-Villiger oxidation of (+)-(1R,5S)-bicyclo[3.3.1]nonane-2,7-dione, 1, can lead to four keto-lactone products, 2a-d. A single isomer is obtained experimentally. We have(More)