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The effect of a truncated form of the neurotoxin beta-amyloid peptide (A beta25-35) on rat brain vascular endothelial cells (RBE4 cells) was studied in cell culture. Toxic effects of the peptide were seen at 200 microg/ml A beta using a mitochondrial dehydrogenase activity (MTT) reduction assay, lactate dehydrogenase release and glucose consumption. Cell(More)
BACKGROUND Satisfaction is the one of the most frequently reported outcome measures for quality of care. Assessment of satisfaction with maternity services is crucial, and psychometrically sound measures are needed if this is to inform health practices. This paper comparatively reviews current measures of satisfaction with care during labour and birth. (More)
OBJECTIVES To assess parents' first experiences of their very preterm babies and the neonatal intensive care unit (NICU). DESIGN Qualitative study using semistructured interviews. PARTICIPANTS 32 mothers and 7 fathers of very preterm babies (<32 weeks gestation). SETTING Three neonatal units in tertiary care hospitals in South East England. RESULTS(More)
OBJECTIVE To describe birth weight and postnatal weight gain in a contemporaneous population of babies born <32 weeks' gestation, using routinely captured electronic clinical data. DESIGN Anonymised longitudinal weight data from 2006 to 2011. SETTING National Health Service neonatal units in England. METHODS Birth weight centiles were constructed(More)
BACKGROUND The admission of a very premature infant to the neonatal intensive care unit (NICU) is often a difficult time for parents. This paper explores parents' views and experiences of the care for their very premature baby on NICU. METHODS Parents were eligible if they had a baby born before 32 weeks gestation and cared for in a NICU, and spoke(More)
A new methodological framework for assessing agreement between cost-effectiveness endpoints generated using alternative sources of data on treatment costs and effects for trial-based economic evaluations is proposed. The framework can be used to validate cost-effectiveness endpoints generated from routine data sources when comparable data is available(More)
BACKGROUND In the UK, 1-2% of infants are born very preterm (<32 weeks of gestation) or have very low birth weight (<1500 g). Very preterm infants are initially unable to be fed nutritional volumes of milk and therefore require intravenous nutrition. Milk feeding strategies influence several long and short term health outcomes including growth, survival,(More)