Jane A. Thomas

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BACKGROUND A new family of next-generation non-animal hyaluronic acid (HA) dermal fillers was approved by the FDA in June 2006. Compared with other HA fillers available in the United States at the time of writing, these new fillers have a higher concentration of HA, higher concentration of cross-linked HA, and a smooth consistency--which should promote(More)
OBJECTIVES To assess the safety and effectiveness of hyaluronic acid (HA) fillers in skin of color. METHODS Two prospective studies followed up subjects with Fitzpatrick skin phototypes of IV, V, or VI for 24 weeks after dermal filler injections. In a double-blind, randomized study, subjects were injected with one of three high concentration (24 mg/mL) HA(More)
Many patients elect to have repeat treatments with hyaluronic acid dermal fillers to maintain wrinkle correction, but the clinical performance of these products after repeat treatments has not been formally assessed. The primary objective of this study was to evaluate the effectiveness of Juvéderm injectable gel (Juvéderm Ultra, Juvéderm Ultra Plus, and(More)
BACKGROUND Juvéderm Ultra injectable gel (Allergan, Inc, Irvine, California) is approved in the United States to treat moderate to severe wrinkles and folds, such as nasolabial folds. It is also used to enhance the appearance of the lips. OBJECTIVES The authors evaluated the safety and effectiveness of Juvéderm Ultra injectable gel for lip enhancement and(More)
BACKGROUND A high concentration of crosslinked hyaluronic acid (HA) in a smooth, malleable formulation is the hallmark of the new Juvéderm dermal fillers. OBJECTIVE To determine the long-term effectiveness and safety of Juvéderm Ultra and Ultra Plus injectable gel. METHODS In the multicenter study approved by the Food and Drug Administration, subjects(More)
INTRODUCTION Pain is a common patient complaint during dermal filler injections. The primary objective of this study was to compare a new formulation of Juvéderm((R)) injectable gel with lidocaine (denoted as JUV + L) to commercially-available Juvéderm((R)) injectable gel without lidocaine (denoted as JUV) with respect to procedural pain scores in subjects(More)
BACKGROUND With the baby boomer generation firmly ensconced in middle age and the ubiquity of botulinum toxin type A, nonsurgical facial rejuvenation is becoming increasingly prevalent. As this generation continues to age, products with greater therapeutic power to correct aging changes will be in growing demand. METHODS A multicenter, double-blind,(More)
BACKGROUND Validated aesthetic rating scales for the perioral area provide objective evaluations for clinical trials and practice. OBJECTIVE To confirm the reliability of 3 scales for evaluating dermal filler and neurotoxin treatments of the perioral area. MATERIALS AND METHODS Three lip-specific photographic scales were developed from standardized(More)
BACKGROUND As lip augmentation becomes more popular, validated measures of lip fullness for quantification of outcomes are needed. OBJECTIVE Develop a scale for rating lip fullness and establish its reliability and sensitivity for assessing clinically meaningful differences. METHODS The initial Allergan Lip Fullness Scale (iLFS; a four-point(More)
Injectable bovine collagen has proven to be safe and effective for the treatment of contour defects for more than 20 years. After intradermal exposure to bovine collagen, the most commonly reported side effect is hypersensitivity (incidence of approximately 3 percent to test and approximately 1 to 2 percent to subsequent treatment). The main purpose of this(More)
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