Janardan P. Pandey

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There is increasing evidence for the involvement of herpes simplex virus type 1 and human cytomegalovirus in the cognitive impairment of patients with schizophrenia (SCZ). Both herpes simplex virus type 1 and human cytomegalovirus have evolved strategies for decreasing the efficacy of the host immune response and interfering with viral clearance.(More)
Studies in both humans and in animal models of specific disorders suggest that polymorphisms of multiple genes are involved in conferring either a predisposition to or protection from autoimmune diseases. Genes encoding polymorphic proteins that regulate immune responses or the rates and extent of metabolism of certain chemical structures have been the(More)
" The roles of nuclear receptors CAR and PXR in hepatic energy metabolism " " Estrogen-enhanced gene expression of lipoprotein lipase in heart is antagonized by progesterone " " Meeting report: batch-to-batch variability in estrogenic activity in commercial animal diets — importance and approaches for laboratory animal research " " Predictors of acquired(More)
BACKGROUND Plasmodium falciparum malaria is a complex disease in which genetic and environmental factors influence susceptibility. IgG isotypes are in part genetically controlled, and GM/KM allotypes are believed to be involved in this control. METHODS In this study, 216 individuals from Daraweesh, an area of seasonal malaria transmission in Sudan, were(More)
Guillain-Barré syndrome is associated with antecedent Campylobacter jejuni infection. Only a minority of the infected individuals, however, develops the disease, implying a role for genetic factors in conferring susceptibility. To determine the role of immunoglobulin KM genes (genetic markers of the constant region of kappa chains) in the etiology of this(More)
Monoclonal antibody (mAb) has fulfilled the promise of being the "Magic Bullet" in oncology with the clinical success of mAbs against CD20, Her-2/neu, epidermal growth factor receptor, vascular endothelial cell growth factor and others in a variety of cancers. Most manufacturers of mouse-human chimeric antibodies (and most immunologists) have treated the(More)
BACKGROUND Humoral immune responses play a key role in the development of immunity to malaria, but the host genetic factors that contribute to the naturally occurring immune responses to malarial antigens are not completely understood. The aim of the present investigation was to determine whether, in subjects exposed to malaria, GM and KM allotypes--genetic(More)
BACKGROUND Tumor necrosis factor (TNF) alpha and TNF-beta are proinflammatory cytokines thought to be involved in the pathogenesis of myasthenia gravis (MG). OBJECTIVE To examine whether TNF polymorphisms are associated with MG, MG subgroups, and the presence of titin and ryanodine-receptor antibodies. PATIENTS AND METHODS We did genotyping on 30(More)
Serum samples were collected from 20 healthy White and 33 Black infants before and after immunisation with three doses of diphtheria-pertussis-tetanus vaccine and with one dose of Haemophilus influenzae type b polyribose phosphate vaccine and meningococcal group A and group C polysaccharide vaccines. Antibodies to these immunogens were measured and sera(More)