Janardan P. Pandey

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Immunoglobulin GM and KM allotypes-genetic markers of gamma and kappa chains, respectively-are associated with immune responsiveness to several infectious pathogens and with survival in certain viral epidemics. We hypothesized that GM and KM allotypes affect the outcome of hepatitis C virus (HCV) infection. To test this hypothesis, we serologically(More)
There is increasing evidence for the involvement of herpes simplex virus type 1 and human cytomegalovirus in the cognitive impairment of patients with schizophrenia (SCZ). Both herpes simplex virus type 1 and human cytomegalovirus have evolved strategies for decreasing the efficacy of the host immune response and interfering with viral clearance.(More)
Studies in both humans and in animal models of specific disorders suggest that polymorphisms of multiple genes are involved in conferring either a predisposition to or protection from autoimmune diseases. Genes encoding polymorphic proteins that regulate immune responses or the rates and extent of metabolism of certain chemical structures have been the(More)
BACKGROUND Plasmodium falciparum malaria is a complex disease in which genetic and environmental factors influence susceptibility. IgG isotypes are in part genetically controlled, and GM/KM allotypes are believed to be involved in this control. METHODS In this study, 216 individuals from Daraweesh, an area of seasonal malaria transmission in Sudan, were(More)
Guillain-Barré syndrome is associated with antecedent Campylobacter jejuni infection. Only a minority of the infected individuals, however, develops the disease, implying a role for genetic factors in conferring susceptibility. To determine the role of immunoglobulin KM genes (genetic markers of the constant region of kappa chains) in the etiology of this(More)
Monoclonal antibody (mAb) has fulfilled the promise of being the "Magic Bullet" in oncology with the clinical success of mAbs against CD20, Her-2/neu, epidermal growth factor receptor, vascular endothelial cell growth factor and others in a variety of cancers. Most manufacturers of mouse-human chimeric antibodies (and most immunologists) have treated the(More)
Mucin 1 (MUC1) is a membrane-bound glycoprotein expressed at low levels by healthy tissues but overexpressed and aberrantly glycosylated in the majority of adenocarcinomas. Among 75 distinct tumor-associated antigens, MUC1 has been ranked second as a priority vaccine target by the NCI Translational Research Working Group. 3 For designing an effective(More)
There are significant interindividual differences in naturally occurring antibody responses to the tumor-associated antigen mucin 1 (MUC1), but the host genetic factors that might contribute to these differences have not been identified. The aim of the present investigation was to determine whether the variation in naturally occurring antibody levels to(More)