Janaque Fernando

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The tricyclic antidepressant (TCA) clomipramine has been widely used in psychiatry for over 40 years. More recently, its therapeutic potential as an antineoplastic drug has been identified. However, there are no prior data on regional distribution in the brain of clomipramine and its primary metabolite (desmethylclomipramine) after chronic oral(More)
RATIONALE Thrombocytopenia is a common problem which causes concern and complications in dengue fever. If proven effective, intravenous fresh frozen plasma is a simple and widely available therapeutic option to manage thrombocytopenia. OBJECTIVE To test the efficacy of fresh frozen plasma (FFP) on thrombocytopenia in patients with dengue fever. DESIGN(More)
INTRODUCTION It is unknown how the timing between doses might affect nicotine's impact on neural activity. Our objective was to examine how the interdose interval affects nicotine's impact on resting-state functional connectivity (rsFC). MATERIALS AND METHODS Adult male Sprague-Dawley rats were administered nicotine daily (0.4 mg/kg) over 6 days while(More)
Twenty-nine patients were treated with haloperidol decanoate, the dosage ranging from 100 to 300 mg i.m. once a month, with duration of treatment ranging from 3-7 months. It seems that haloperidol decanoate could be useful in schizo-affective disorder/depressed type and also in manic disorder. The investigators were impressed by the relative lack of side(More)
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