Janakiraman Vani

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BACKGROUND Adjuvants enhance or modify an immune response that is made to an antigen. An antagonist of the chemokine CCR4 receptor can display adjuvant-like properties by diminishing the ability of CD4+CD25+ regulatory T cells (Tregs) to down-regulate immune responses. METHODOLOGY Here, we have used protein modelling to create a plausible chemokine(More)
Autoimmunity refers to an inappropriate immune response against self-components of the host that results in pathological conditions. Autoimmune diseases are characterized by an activation of autore-active T and B cells, are associated in some cases with the production of patho-genic autoantibodies against self-molecules , culminating in inflammation and(More)
Synthetic CpG containing oligodeoxynucleotide Toll like receptor-9 agonist (CpG DNA) activates innate immunity and can stimulate antigen presentation against numerous intracellular pathogens. It was observed that Salmonella Typhimurium growth can be inhibited by the CpG DNA treatment in the murine dendritic cells. This inhibitory effect was mediated by an(More)
Dendritic cells (DCs) are professional antigen presenting cells, which play a crucial role both in maintaining immune tolerance and in inducing adaptive immune responses. Therefore, DCs are the most sought in inciting autoimmu-nity and its sustenance to autoimmune diseases. The emerging knowledge of the importance of DCs, DC-derived cytoki-nes, and(More)
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