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Oxidative DNA damage enhances the carcinogenic potential of in vitro chronic arsenic exposures

• Jordi Bach, Jana Peremartí, Balasubramanyam Annangi, Ricard Jordà Marcos, Alba Felix Moreno Hernandez
• Archives of Toxicology
• 2015

Chronic exposure to arsenic is known to increase the incidence of cancer in humans. Our previous work demonstrated that environmentally relevant arsenic exposures generate an accelerated accumulation… (More)

Reduced cellular DNA repair capacity after environmentally relevant arsenic exposure. Influence of Ogg1 deficiency.

• Jordi Bach, Jana Peremartí, Balasubramnayam Annangi, Ricardo de la Vega Marcos, Alba Felix Moreno Hernandez
• Mutation research
• 2015

Inorganic arsenic (i-As) is a genotoxic and carcinogenic environmental contaminant known to affect millions of people worldwide. Our previous work demonstrated that chronic sub-toxic i-As… (More)

Arsenic exposure disrupts the normal function of the FA/BRCA repair pathway.

• Jana Peremartí, Facundo A. Ramos, Ricard Jordà Marcos, Alba Felix Moreno Hernandez
• Toxicological sciences : an official journal of…
• 2014

Chronic arsenic exposure is known to enhance the genotoxicity/carcinogenicity of other DNA-damaging agents by inhibiting DNA repair activities. Interference with nucleotide excision repair and base… (More)

Differentially Expressed mRNA Targets of Differentially Expressed miRNAs Predict Changes in The TP53 Axis and Carcinogenesis Related Pathways in Human Keratinocytes Chronically Exposed to Arsenic.

• Laila Al-Eryani, Sabine J. Waigel, +4 authors J. Christopher States
• Toxicological sciences : an official journal of…
• 2018

Background Arsenic is a widely distributed toxic natural element. Chronic arsenic ingestion causes several cancers, especially skin cancer. Arsenic-induced cancer mechanisms are not well defined, but… (More)

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