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The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase
Evidence is presented that a protein that binds to J in DNA, the J-binding protein 1 (JBP1), may also catalyze the first step in J biosynthesis, the conversion of thymine in DNA into hydroxymethyluracil and it is proposed that JBP1 is a thymidine hydroxylase responsible for the local amplification of J inserted by JBP2, another putative thymalid hydroxyase.
Teaching Biochemistry and Genetics to Students of Medicine, Pharmacy, and Dentistry
Teaching Biochemistry and Genetics to Students of Dentistry, Medicine, and Pharmacy 6th International Conference of the Association of Biochemistry Educators (ABE) Clearwater Beach, FL, USA, May…
Eric C. Niederhoffer1, Susan D. Cline2, Neil Osheroff3, Jana M. Simmons4, Alan B. Diekman5, David S. Franklin6, Emine E. Abali7, Robert C. Bateman Jr.8, Joseph D. Fontes9, Janet E. Lindsley10, David…
Fe(II)/alpha-ketoglutarate hydroxylases involved in nucleobase, nucleoside, nucleotide, and chromatin metabolism.
This Perspective focuses on a subgroup of Fe(II)/alpha-ketoglutarate-dependent hydroxylases that are involved in pyrimidine salvage, purine decomposition, nucleoside and nucleotidehydroxylation, DNA/RNA repair, and chromatin modification.
Trypanosoma brucei brucei: thymine 7-hydroxylase-like proteins.
Characterization of a Trypanosoma brucei Alkb homolog capable of repairing alkylated DNA.
Training Students to Answer Layman’s Questions Also Helps in Retention of Scientific Content
We report a curricular exercise with two principal goals: (a) training medical students to integrate several key elements derived from basic science content to answer patient’s question and (b)…
Characterization of four members of the ferrous ion and alpha-ketoglutarate dependent hydroxylase family from Trypanosoma brucei: Two thymine hydroxylase-like proteins, J-binding protein 1, and an…
- Jana M Simmons
Serves as a Potent Negative Regulator of Hematopoiesis by Human Hematopoietic Progenitors and Bone Marrow Stromal Cells That The Sialomucin CD164 (MGC-24v) Is an Adhesive Glycoprotein Expressed
This dissertation aims to provide a history of web exceptionalism from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate.