Jana Haddow

  • Citations Per Year
Learn More
Introduction The lifetime risk of developing HTLV-1 associated myelopathy (HAM) is 0.25-3%. The main pathological feature is an immune-mediated response leading to chronic inflammation of the spinal cord. The optimal long term treatment has yet to be determined although clinical improvement with ciclosporin has been shown in a pilot study. Methotrexate,(More)
The efficacy of treatments used for patients with HTLV-1 associated myelopathy/tropical spastic paraperesis (HAM/TSP) is uncertain although corticosteroids are widely prescribed. The effect of pulsed IV methylprednisolone was retrospectively analysed in an open cohort of 26 patients. 1g IV methylprednisolone was infused on three consecutive days. The(More)
Human T-cell Lymphotropic virus (HTLV) prevalence is low in the UK, but higher in individuals originating from endemic countries. Anti-HTLV screening of all blood donations was introduced in 2002 to reduce the risk of transfusion transmission. The UK HTLV Cohort (UHC) was established for longterm follow up of people affected by HTLV. Recruitment by(More)
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an immune mediated myelopathy caused by the human T-lymphotropic virus type 1 (HTLV-1). The efficacy of treatments used for patients with HAM/TSP is uncertain. The aim of this study is to document the efficacy of pulsed methylprednisolone in patients with HAM/TSP. Data from an open(More)
Adult T-cell lymphoma/leukaemia (ATLL) is known to be associated with poor immune response. Currently, it is not clear whether this is contributory to, or the consequence of the development of ATLL. In the National Centre for Human Retrovirology (NCHR) in London, we measured CD8/DR expression (a marker of T-cell activation) at ATLL presentation in our(More)
  • 1