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To evaluate changes in lipoprotein lipase (LPL) expression during development, levels of LPL mRNA, protein, and enzyme activity were measured in heart, epididymal fat, kidney, and brain of rats, from late gestation through 24 mo. LPL mRNA, protein, and enzyme activity were low in fetal and neonatal hearts. LPL mRNA increased 11-fold by 60 days and remained(More)
Diabetes mellitus is associated with a reduction of lipoprotein lipase (LPL) activity and development of hypertriglyceridemia. In the current experiments the mechanisms involved in the regulation of LPL have been examined in control rats, streptozocin-induced diabetic rats, and diabetic rats treated chronically or with a single injection of insulin.(More)
At the first gate of an innovation process, a large number of raw ideas must be evaluated and those good enough to continue to the next phase be selected. No information about these ideas is available, so they have a high level of uncertainty. We present an algorithm that selects and ranks a set of alternatives in optimal time. The algorithm addresses(More)
This paper describes a course in innovation offered to students at the University of Magdeburg in Germany. The course is based on the premise that idea generation can be viewed as a methodical discipline, and offers a unique combination of the psychological framework for creative thinking, the business background for innovation and state-of-theart(More)
At the first gate of an innovation process, a group of experts has to partition a large number of illdefined ideas into two sets: those that are to remain under consideration and those that are to be eliminated. We propose a collaborative algorithm to perform this task which is based on a method used in computer-based sorting. The design goal of our(More)
In order to maintain competitiveness, companies must constantly find new and better business ideas. They use innovation processes for managing idea generation and implementation. This process involves the employees that will be responsible for the implementation of these ideas, and the success of an innovation venture depends on their motivation. Especially(More)
The fastest way for a group of experts to select raw ideas is in parallel. However, since each expert then no longer sees the large majority of the individual decisions, there is a danger that consensus about the result will be low. Ideally, the result of the parallel selection would be identical to the one that the group would have produced(More)
We are interested in the problem of evaluating and selecting one or more ideas to be pursued in the idea stage of the innovation process. The so-called scoring method, which is based on Multi-Attribute Utility Theory is very commonly used for this task. We know of many corporations that select their innovation projects using this technique. We present(More)
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