JanWillem Duitman

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The prognosis of bacterial meningitis largely depends on the severity of the inflammatory response. The transcription factor CAAT/enhancer-binding protein δ (C/EBPδ) plays a key role in the regulation of the inflammatory response during bacterial infections. Consequently, we assessed the role of C/EBPδ during experimental meningitis. Wild-type and(More)
Protease-activated receptor (PAR)-4 is a thrombin receptor expressed in lung tissue. Previous in vitro data showed that PAR-4 triggers epithelial-to-mesenchymal transition, which is crucial in pulmonary fibrosis. These observations prompted us to investigate the role of PAR-4 in a murine model of bleomycin induced pulmonary fibrosis. We observed that(More)
Endogenously administered activated protein C ameliorates diabetic nephropathy (DN) in a protease-activated receptor-1 (PAR-1)-dependent manner, suggesting that PAR-1 activation limits the progression of DN. Activation of PAR-1 in fibroblast-like cells, however, induces proliferation and extracellular matrix production, thereby driving fibrotic disease.(More)
BACKGROUND The most frequent pathogen that causes bacterial meningitis is the Gram-positive bacterium Streptococcus (S.) pneumoniae. CCAAT/enhancer binding protein δ is a transcription factor that has recently been hypothesized to play a detrimental role in outcome of meningitis caused by S. pneumoniae. Here, we studied the role of C/EBPδ prior to the(More)
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