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BACKGROUND The role of serial NT-proBNP measurements in patients suffering from chronic systolic heart failure (CHF) who already receive individually optimized pharmacotherapy is still unresolved. METHODS NT-proBNP was assessed at baseline and at 6 months follow-up in 504 stable CHF patients treated with individually optimized pharmacotherapy. After(More)
BACKGROUND The average diagnostic sensitivity of exercise stress tests (ESTs) is lower than that of other non-invasive cardiac stress tests. The aim of the study was to examine whether high-sensitivity cardiac troponin T (hs-cTnT) or copeptin concentrations rise in response to inducible myocardial ischaemia and may improve the diagnostic accuracy of ESTs.(More)
AIMS To investigate determinants and temporal developments of treatment strategies, 5-year survival and heart transplantation rates between patients treated at secondary and tertiary hospitals. METHODS AND RESULTS Baseline characteristics, treatment and follow-up data from 2,023 patients with chronic systolic heart failure due to ischaemic or dilated(More)
The aim of the study is to evaluate the use of beta-blockers in chronic heart failure (CHF) and the extent of heart rate reduction achieved in clinical practice and to determine differences in outcome of patients who fulfilled select inclusion criteria of the SHIFT study according to resting heart rate modulated by beta-blocker therapy. We evaluated an(More)
Several modeling domains make use of three-dimensional representations, e.g., the " ball-and-stick " models of molecules. Our generator framework DEViL3D supports the design and implementation of visual 3D languages for such modeling purposes. The front-end of a language implementation generated by DEViL3D is a dedicated 3D graphical structure editor, which(More)
  • Jan Wolter
  • 2013
Several modeling domains make use of three-dimensional representations, e.g., the “ball-and-stick” models of molecules. Our generator framework DEViL3D supports the design and implementation of visual 3D languages for such modeling purposes. The front-end of a language implementation generated by DEViL3D is a dedicated 3D graphical structure(More)
CONTEXT Troponin T upstream open reading frame peptide (TnTuORF) may be useful as a novel biomarker in acute cardiac syndromes. OBJECTIVE The study examined the early release kinetics of TnTuORF. MATERIALS AND METHODS We analyzed the time course of the release of cardiac troponins I and T and TnTuORF in patients (n = 31) with hypertrophic obstructive(More)
The implementation of three-dimensional visual languages requires a wide range of conceptional and technical knowledge on issues for 3D graphics and textual language processing. Our generator framework DEViL3D incorporates such knowledge and supports the design of visual 3D languages and their implementation from high-level specifications. Such 3D languages(More)