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Twenty-two patients with Sjögren's syndrome uncomplicated by a connective tissue disorder, 31 with Sjögren's syndrome complicated by rheumatoid arthritis, and 21 with rheumatoid arthritis alone were studied with particular reference to changes in the ears and in the upper respiratory and digestive tracts.Epistaxis, soreness and dryness of the throat,(More)
Trophozoites of 4 species of Acanthamoeba were cytopathic for cultured rat B103 neuroblastoma cells. Cytopathogenicity was evaluated by a chromium release assay and by transmission and scanning electron microscopy. Acanthamoeba culbertsoni, Acanthamoeba castellanii, and Acanthamoeba polyphaga destroyed B103 target cells at 37 C as evidenced by the release(More)
Sir William Read, Royal Ophthalmologist during the reign of Queen Anne (1702-17I4), who incidentally was unable to read or write (Guthrie, 1958), gave a choice description of the dangers of perforation in deep scleritis: 'For it is most certain that this horny membrane . . . by how much deeper the blister is hidden in the membrane . . . in danger to make an(More)
A clinicopathological correlation was performed on 24 patients suffering from keratoconjunctivitis sicca (KCS). Examination of conjunctival biopsies by light and transmission electron microscopy revealed stratification of the conjunctival epithelium with separation of the superficial cell layers, and this was directly proportional to the clinical severity(More)
Commercial ophthalmic chloramphenicol solutions and ointments were applied to human eyes, and the concentrations of chloramphenicol in aqueous humor and tear samples were analyzed using gas-liquid chromatography. Within several minutes after a single application of 0.5% chloramphenicol solution, the tear concentrations of the drug had fallen below 1(More)
The authors quantified improvement in predicting cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma of the skin made possible by information on common variants of the melanocortin-1 receptor gene (MC1R) in a 1998-1999 population-based case-control study of subjects aged 20-59 years of northern European ancestry in Tasmania,(More)
Ocular complications associated with long-term systemic corticosteroid therapy include the development of posterior subcapsular cataracts adrenocorticotrophic hormone has been implicated in the causation ofposterior subcapsular cataracts (Crews, I963), glaucoma (Alfano and Platt, I966), and the simultaneous appearance of macular lesions and posterior(More)
OBJECTIVE Clinical experience suggests that reflexology may have beneficial effects on the symptoms occurring in menopausal women, particularly psychological symptoms. This study aims to examine that effect rigorously. DESIGN Randomised controlled trial with two parallel arms. SETTING School of Complementary Health in Exeter, Devon, UK. SAMPLE(More)