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During 1968-1971, 8763 samples were collected at 59 sites in U.S. cities for a study of particulate lead concentrations in air. Each site was sampled continuously for a full year. These samples have been analyzed for total suspended particulate matter and for cadmium, chromium, lead, manganese, nickel, and zinc. Results of over 42 000 analyses are(More)
Top dieback in 40-60 years old forest stands of Norway spruce [Picea abies (L.) Karst.] in southern Norway is supposed to be associated with climatic extremes. Our intention was to learn more about the processes related to top dieback and in particular about the plasticity of possible predisposing factors. We aimed at (i) developing proxies for P 50 based(More)
A synthesis of novel pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged pyrazolo-, tetrazolo-, benzimidazo-, and thiazolopyrimidines via Hantzsch- and Biginelli-like condensations has been developed. The ability of these compounds to inhibit Eg5 activity has been examined. The results indicate that synthetic manipulations in the monastrol(More)
Presented Models describe the current growth rate. These models are good tools for growth prediction in the near future and will be compareable with further models; they will demonstrate the Norway spruce growth changes considering the climate change. Tree growth depends on genetic, climatic, microsite conditions and stand structure variations. A new(More)
The X-ray structure analysis of the unexpected product of the reaction between 4-(4-methylphenyl)but-3-en-2-one and aminoguanidine revealed the title compound, C(12)H(17)N(4)(+) x -C(2)H(3)O(2)(-) x 0.5C(3)H(6)O, consisting of a protonated amidine moiety joined to a substituted pyrazoline ring at the N1 atom. The amidine group is protonated and the positive(More)
Estimating emissions at the level of countries, states, regions or provinces and even larger companies in most cases is a knowledge-intensive exercise. Guidelines, guidebooks and other guidance documents to prepare emissions inventories typically contain thousands of pages with emission estimation methods and specific and aggregated emission factors for(More)
The pharmacology of dihydropyridines in the cardiovascular system is widely known and the effects on L-type channels are well researched. There is far less information about the action of dihydropyridines on other classes of voltage-gated calcium channels. This article aims to bring more information about dihydropyridine derivates action on voltage-gated(More)
The title compound, C(13)H(14)N(2)OS, crystallizes as a racemate in a non-chiral space group. It represents a conformationally restricted analogue of so-called Biginelli compounds known to exhibit multiple pharmacological activities and was selected for a single-crystal X-ray analysis in order to probe the chemical and spatial requirements of some kinds of(More)
In the title compound, C(18)H(16)N(2)O(3), a potential inhibitor of the cyclo-oxygenase-2 isoenzyme, the pyrazoline ring exists in a flattened envelope conformation with one C atom deviating by 0.463 Å from the mean plane of the remaining four atoms. The puckering of the central oxazine ring is more severe, with one N atom and one C atom displaced by 0.235(More)
Voltage-gated Ca2+ channels are the major pathway of Ca2+ entry into the cells. Their activity is essential to couple electrical signals from the cell surface to physiological events in cells. Several pharmacologically, structurally and kinetically distinct calcium channel types have been identified at the electrophysiological and molecular levels. This(More)