Jan S Niemeier

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Secondary mechanical hyperalgesia has been demonstrated in postoperative patients indicating that central sensitization occurs after surgery. However, the underlying mechanisms are unknown. Here, we studied the role of spinal AMPA/kainate receptors for pain behaviors indicating secondary hyperalgesia caused by gastrocnemius incision in the rat. These were(More)
In klinischen Studien wurde bei postoperativen Patienten eine mechanische Hyperalgesie rund um die Operationswunde nachgewiesen. Dieses Phänomen der sekundären Hyperalgesie weist darauf hin, dass nach einer Operation eine zentrale Sensibilisierung eintritt, die evtl. zu chronischen postoperativen Schmerzen führen kann. Die zugrunde liegenden Mechanismen(More)
Secondary hyperalgesia, an exaggerated response to stimuli applied to undamaged tissue surrounding an injury, is a common consequence of tissue injury and inflammation. It is well established that the etiology of secondary hyperalgesia is sensitization of central neurons but the exact mechanism and its role in certain clinical pain states is unclear. In the(More)
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