Jan R. Schultz

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The spatial heterogeneity of myocardial perfusion and metabolism was studied in 11 anaesthetized dogs under resting conditions. In each heart local myocardial blood flow was assessed using the tracer microsphere technique in 256 samples (mean mass: 83.1 mg) taken from the left anterior ventricular wall. In the same samples, the following biochemical(More)
Recent global warming is acting across marine, freshwater, and terrestrial ecosystems to favor species adapted to warmer conditions and/or reduce the abundance of cold-adapted organisms (i.e., "thermophilization" of communities). Lack of community responses to increased temperature, however, has also been reported for several taxa and regions, suggesting(More)
With more than 10 years of practical experience and theoretical analysis, fragment-based drug discovery (FBDD) has entered the mainstream of the pharmaceutical and biotech industries. An array of biophysical techniques has been used to detect the weak interaction between a fragment and the target. Each technique presents its own requirements regarding the(More)
Diversity in temperate forests is concentrated in the understory, but understory dynamics are poorly understood for old-growth forests. We use repeated measurements of more than eight hundred 1 m2 plots over three decades to assess patterns of understory diversity in old-growth mesic and wet forests in northern Michigan, USA. We ask whether diversity(More)
The ultimate role of the computer in the delivery of health services has yet to be defined. There may be profound implications in terms of quality of medical care, efficiency, economics of care, and medical research. Final judgments as to advisability and economic feasibility await the implementation of prototype total medical information systems and(More)
Jan Schultz has lived in Burlington, Vermont for the last 17 years. He was associated with the University of Vermont from 1969 until 1981 as a Research Associate in the College of Medicine. He coordinated computer related activities at PROMIS Laboratory during that period and conducted research in programming languages and database systems. In 1981 he left(More)
In 2015, the Advisory Committee on Immunization Practices issued updated recommendations for the use of 13-valent pneumococcal conjugate vaccine (PCV13) and 23-valent pneumococcal polysaccharide vaccine (PPSV23) to immunize adults aged 19 to 64 years with risk factors and all adults aged 65 years or older. Despite these recommendations, rates of vaccination(More)
PURPOSE Opioid diversion, misuse, and abuse are rapidly growing problems in the United States; >60% of all drug overdose deaths involve an opioid. At least 49 states now have fully operational prescription drug monitoring programs (PDMPs) to support legitimate medical use of controlled substances; however, there is considerable underutilization of such(More)