Jan Pieter Smits

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A description is given of the solid-state fermentation of wheat bran by Trichoderma reesei QM9414 at constant temperature and relative humidity. Glucosamine, the oxygen consumption rate (OCR), the carbon dioxide production rate (CPR), changes in wheat bran composition and the production of four enzymes were measured during 125 h of fermentation. A C balance(More)
A degradation pathway for dl-α-phenylhydracrylic, phenylacetic, 3- and 4-hydroxyphenylacetic acid by a Flavobacterium is presented. Experiments with washed cells and enzyme studies revealed that dl-α-phenylhydracrylic acid in an initial reaction was oxidatively decarboxylated to phenylacetaldehyde. Whole cells oxidized both stereoisomers of(More)
Two fungal strains, Aspergillus clavatus II-9 and Fusarium oxysporum @ 149, proved to be capable of degrading sinigrin and sinalbin. During the degradation of sinigrin by whole cells of the Aspergillus strain, allylcyanide accumulated in the liquid incubation mixture. After a maximum concentration had been reached, the concentration of allylcyanide(More)
A strain of Pseudomonas putida capable of utilizing both stereoisomers of phenylglycine as the sole carbon and energy source was isolated from soil. No phenylglycine racemase was detected in cells grown on either stereoisomer. In an initial reaction each steroisomer of phenylglycine was transaminated yielding phenylglyoxylate which was further metabolized(More)
We report the results from intraarterial digital subtraction angiography (IA DSA) of the extracerebral vessels with aortic arch injection of contrast medium via femoro-arterial puncture, instead of the more widely used intravenous digital subtraction angiography (IV DSA). Intraarterial DSA is performed using a lower contrast dose and rate, making this study(More)
A novel solid-state fermentation method using polyurethane foam as inert carrier impregnated with a synthetic liquid medium was developed simulating the nutritional composition and culture conditions of solid-state fermentation on wheat bran. With this system, biomass, the important parameter involved in solid-state fermentation processes, can be measured(More)
A case of fibromuscular dysplasia (FMD) of the internal carotid artery was treated by percutaneous transluminal angioplasty (PTA) using a Grüntzig balloon. A control angiographic study performed with intravenous digital subtraction angiography (IV DSA) showed a completely patent dilated vessel. This result, together with the total relief of clinical signs(More)
Pseudomonas putida LW-4, isolated on D-phenylglycine as sole carbon and energy source, was also able to grow on D-3-and D-4-hydroxyphenylglycine. Both D-3-and D-4-hydroxyphenylglycine were initially converted to the corresponding hydroxyphenylglyoxylates by means of an enantioselective transaminase. Subsequently, the hydroxyphenylglyoxylates were(More)
Industrialization and urbanization are seen as interdependent processes of modern economic development. However, the exact nature of their causal relationship is still open to considerable debate. This paper uses firm-level data from the manuscripts of the decennial censuses between 1850 and 1880 to examine whether the adoption of the steam engine as the(More)
In this paper we analyze the dynamics of Dutch economic growth for the period 1815-1997. By applying a simple econometric technique, important braking points in the timeseries are traced. It seems that three phases of growth can be discerned and that these phases are characterized by different types of technology (steam, electricity as well as information(More)