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The NMRPipe system is a UNIX software environment of processing, graphics, and analysis tools designed to meet current routine and research-oriented multidimensional processing requirements, and to anticipate and accommodate future demands and developments. The system is based on UNIX pipes, which allow programs running simultaneously to exchange streams of(More)
  • L Godley, J Pfeifer, D Steinhauer, B Ely, G Shaw, R Kaufmann +4 others
  • 1992
Influenza virus hemagglutinin (HA) mediates viral entry into cells by a low pH-induced membrane fusion event in endosomes. A number of structural changes occur throughout the length of HA at the pH of fusion. To probe their significance and their necessity for fusion activity, we have prepared a site-directed mutant HA containing novel intersubunit(More)
Real-world machine learning applications may require functions to be fast-to-evaluate and interpretable, in particular, guaranteed monotonicity of the learned function can be critical to user trust. We propose meeting these goals for low-dimensional machine learning problems by learning flexible, monotonic functions using calibrated interpolated look-up(More)
All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means, electronic or mechanical, including photocopying, recording or any information storage and retrieval system now known or to be invented, without written permission from the Publisher. This book is dedicated to the loving memory of my parents, Georgios and(More)
For many machine learning problems, there are some inputs that are known to be positively (or negatively) related to the output, and in such cases training the model to respect that monotonic relationship can provide regularization, and makes the model more interpretable. However, flexible monotonic functions are com-putationally challenging to learn beyond(More)
Implementation of whole slide imaging in surgical pathology: A value added approach. Abstract Background: Whole slide imaging (WSI) makes it possible to capture images of an entire histological slide. WSI has established roles in surgical pathology, including support of off-site frozen section interpretation, primary diagnosis, educational activities, and(More)
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