Jan Pavlík

  • Citations Per Year
Learn More
Brief heating of Bacillus Licheniformis cell walls at 100 degrees C in aqueous buffers of pH3.0-4.0 removes some polymers but not others from the mucopeptides. For example, relatively undegraded teichuronic acid can be extracted at 100 degrees C in 20min at pH3.0 whereas the teichoic acids are not removed. Similar specificity can be shown with walls from(More)
Entecavir (ETV) is one of the most potent agents for the treatment of the hepatitis B viral infection. The drug is principally eliminated by the kidney. The goal of this study was to investigate the potential of ETV to interact in vitro with the renal SLC transporters hOAT1, hOCT2, hCNT2 and hCNT3. Potential drug-drug interactions of ETV at the renal(More)
The mononuclear compound (1) [Fe(II)(L)(2)](BF(4))(2) (L = 4-ethynyl-2,6-bis(pyrazol-1-yl)pyridine) was prepared and structurally as well as magnetically characterised. The crystallisation revealed the formation of two polymorphs--the orthorhombic 1A and the tetragonal form 1B. A third, intermediate phase 1C was found exhibiting a different orthorhombic(More)
We define varieties of algebras for an arbitrary endofunctor on a cocomplete category using pairs of natural transformations. This approach is proved to be equivalent to one of equational classes defined by equation arrows. Free algebras in the varieties are investigated and their existence is proved under the assumptions of accessibility. In universal(More)
  • Jan Pavlík
  • Journal of Mathematical Imaging and Vision
  • 2014
The method of fuzzy segmentation of a digital image is generalized to the framework of L-fuzzy sets. Such an approach enables the use of various user-defined criteria for comparison of pairs of objects. These criteria are merged into a single mapping whose codomain is a poset. Then a free lattice structures are introduced and the procedure of L-fuzzy(More)
3-(4-bromophenyl)-5-acetyloxymethyl-2,5-dihydrofuran-2-one (LNO-18-22) is a representative member of a novel group of potential antifungal drugs, derived from a natural 3,5-disubstituted butenolide, (-)incrustoporine, as a lead structure. This lipophilic compound is characterized by high in vitro antifungal activity and low acute toxicity. For the purpose(More)
A series of 3-aryl-5-acyloxymethyl-5,6-dihydro-2H-pyran-2-ones, related to highly antifungally active butenolides, was synthesized via cyclization of substituted δ-hydroxy acids as the key step, and evaluated for their in vitro antifungal activity and cytostatic activity. While the extension of the furanone ring to pyranone led to a complete loss of the(More)