Jan Paul

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BACKGROUND To strengthen research and differential diagnostics of mitochondrial disorders, we constructed and validated an oligonucleotide microarray (h-MitoArray) allowing expression analysis of 1632 human genes involved in mitochondrial biology, cell cycle regulation, signal transduction and apoptosis. Using h-MitoArray we analyzed gene expression(More)
BACKGROUND The objective of this study was the quantification of myocardial motion from 3D tissue phase mapped (TPM) CMR. Recent work on myocardial motion quantification by TPM has been focussed on multi-slice 2D acquisitions thus excluding motion information from large regions of the left ventricle. Volumetric motion assessment appears an important next(More)
PURPOSE To compare the applicability of different self-gating (SG) strategies for respiratory SG in cardiac MRI in combination with iteratively reconstructed (k-t SPARSE SENSE) cine data with low and high temporal resolution. METHODS Eleven SG variants were compared in five volunteers by assessment of the resulting image sharpness compared with nongated(More)
PURPOSE The combination of fully balanced SSFP sequences with iterative golden angle radial sparse parallel (iGRASP) MRI leads to strong image artifacts due to eddy currents caused by the large angular increment of the golden angle ordering. The purpose of this work is to enable the combination of iterative golden angle radial sparse parallel MRI with(More)
PURPOSE To investigate the combination of Golden Angle Radial Sparse SENSE reconstruction with image-based self-gating (SG) for deriving high-quality TPM data from radial golden angle (GA) k-space data. METHODS In 10 healthy volunteers, a self-gated radial GA TPM sequence (TPMSG ) was compared with a prospectively triggered radial TPM acquisition with(More)
PURPOSE To combine image-based self-gating (img-SG) with ultrashort echo time (UTE) three-dimensional (3D) acquisition for multistage lung imaging during free breathing. METHODS Three k-space ordering schemes (modified spiral pattern, quasirandom numbers and multidimensional Golden Angle) providing uniform coverage of k-space were investigated for(More)