Jan Oberdoerster

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Although humans have been exposed to airborne nanosized particles (NSPs; < 100 nm) throughout their evolutionary stages, such exposure has increased dramatically over the last century due to anthropogenic sources. The rapidly developing field of nanotechnology is likely to become yet another source through inhalation, ingestion, skin uptake, and injection(More)
Cerebellar Granule Cells in Neurotoxicology (Jan Oberdoerster, Aventis Corporation, Research Triangle Park, North Carolina). Cultured neurons allow the researcher to investigate mechanisms of toxicity on a relatively uniform population of cells. Primary cultures of cerebellar granule cells are post-mitotic neurons that are readily isolated and may be used(More)
Metric and Response Metric Wittmaack (2007) did not agree with our suggestion (Oberdörster et al. 2005) that particle surface area is a more appropriate dose metric than particle mass or particle number when evaluating dose–response relationships of nanoparticle-induced pulmonary inflammation. According to his understanding of nanotoxicology and based on(More)
Toluene, an inexpensive and available industrial solvent, has become increasingly popular as a drug of abuse. Inhaling toluene leads to a feeling of euphoria and several reports have shown that children born to women who had abused toluene during pregnancy present a syndrome (toluene embryopathy or fetal solvent syndrome) that is characterized by CNS(More)
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