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Stimulation of phospholipase C (PLC) by G(q)-coupled receptors such as the M(3) muscarinic acetylcholine receptor (mAChR) is caused by direct activation of PLC-beta enzymes by Galpha(q) proteins. We have recently shown that G(s)-coupled receptors can stimulate PLC-epsilon, apparently via formation of cyclic AMP and activation of the Ras-related GTPase(More)
The irises of both Lophius piscatorius (goosefish) and Opsanus tau (toadfish), like those of many other vertebrates, have a photosensitive sphincter pupillae that responds autonomously to light. The iris also constricts when exposed to either cholinergic or adrenergic agonists. Our data suggest that the adrenergic response is nonspecific and that the irises(More)
An attempt has been made to characterize the photoreceptors and neurons of the frontal organ of Rana pipiens and the synaptic contacts of these cells, in order to provide morphological correlates for previous physiological findings. Neurons, glial cells, and photoreceptors with two different appearances can be seen in normal anatomical preparations. The(More)
Receptor tyrosine kinase regulation of phospholipase C-epsilon (PLC-epsilon), which is under the control of Ras-like and Rho GTPases, was studied with HEK-293 cells endogenously expressing PLC-coupled epidermal growth factor (EGF) receptors. PLC and Ca(2+) signaling by the EGF receptor, which activated both PLC-gamma1 and PLC-epsilon, was specifically(More)
The effects of 2-[beta-(4-hydroxyphenyl)-ethyl-aminomethyl]-tetralone (BE 2254) on pre- and postsynaptic alpha-adrenoceptors were studies in isolated rabbit hearts and strips of rabbit pulmonary arteries. The KCl (80 mM)-evoked output of endogenous noradrenaline from perfused hearts was significantly increased by BE 2254 (10(-7)-10(-6) M). The inhibitory(More)