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9 mmHg, and CRS increased from 26 to 46 ml/cmH2O (Fig. 1). PaO2/FIO2 ratio increased from 95 to 170. Noradrenaline infusion was decreased from 0.8 to 0.4 μg/kg per minute. CVP during fluid removal was in normal range. The patient died on the 17th day due to septic shock. The second case was that of a 40-yearold man was admitted to our ICU with severe sepsis(More)
Abdominal compartment syndrome (ACS) is defined as a sustained increase of intra-abdominal pressure (IAP) above 20 mmHg followed by the development of organ dysfunction. Treatment of ACS is still a question to be discussed and surgical decompression is usually preferred. According to recent data, massive crystalloid resuscitation of shock plays a key role(More)
Pseudomonas aeruginosa is one of the most frequent and dangerous pathogens involved in the etiology of severe nosocomial infections. A retrospective observational study was conducted at all intensive care units of the University Hospital in Olomouc, Czech Republic (155 ICU beds). Complete antibiotic utilization data of the ICUs in the period of 1999 to 2008(More)
Evaluation of procalcitonin levels is a sensitive investigation which is significant for differentiation between microbial and non-microbial infection, a determination of its dynamics and a prediction of therapy results. It is, however, necessary to evaluate its levels in relation to other investigations and their dynamics (other inflammatory markers, organ(More)
BACKGROUND The impact of different approaches to fluid management during intraoperative volume resuscitation in patients undergoing major elective surgery is poorly defined. We compared volume effectiveness of crystalloid and colloid substitution aimed to maintain the cardiac index (CI) between 2.6 and 3.8 l/min/m(2) as measured by transesophageal Doppler(More)
Excessive forms of the response of organism to infection play an important role in the pathogenesis of severe sepsis. They may consist of either local pro-inflammatory response with a massive release of cytokines into the systemic circulation, or may be presented as an excessive systemic anti-inflammatory response. In the first case, the result is a(More)