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1,25-dihydroxyvitamin D3 (1,25-D3) is already known to prevent clinical signs of experimental allergic encephalomyelitis when animals are treated during the immunization phase. In the present work we have evaluated the ability of 1,25-D3 to inhibit chronic relapsing experimental allergic encephalomylitis (EAE) of the Lewis rat, when administered after the(More)
BACKGROUND Controversy exists about the timing of the initiation of parenteral nutrition in critically ill adults in whom caloric targets cannot be met by enteral nutrition alone. METHODS In this randomized, multicenter trial, we compared early initiation of parenteral nutrition (European guidelines) with late initiation (American and Canadian guidelines)(More)
BACKGROUND Critically ill infants and children often develop hyperglycaemia, which is associated with adverse outcome; however, whether lowering blood glucose concentrations to age-adjusted normal fasting values improves outcome is unknown. We investigated the effect of targeting age-adjusted normoglycaemia with insulin infusion in critically ill infants(More)
A novel massively-parallel fine-grain architecture featuring a digital emulation of Cellular Nonlinear Networks (CNN) is presented. A virtual cellular network is processed line-by-line by a locally connected linear array of processing elements. The resulting computing system is able to execute complex CNN program code consisting of consecutive operations.(More)
Pentoxifylline, a widely used methylxanthine, has been proven to inhibit the production and action of the cytokine TNF alpha. Since it has been suggested that TNF alpha is the major cytokine involved in the pathogenesis of multiple sclerosis, we tested pentoxifylline for its capacity to prevent experimental allergic encephalomyelitis (EAE). 26 Lewis rats(More)
In this contribution we present a CNN video processing system that takes full advantage of a digital CNN Universal Machine (CNN-UM) using the recently-introduced NERO architecture. The proposed system is fully configurable in terms of network size and data precision. Using a Xilinx Zynq-7000 SoC we implemented a network of 512 × 900 cells at 8 bit,(More)
Emulations of cellular nonlinear networks (CNN) on digital reconfigurable hardware have proved to be adequate for highly-efficient computation of massive data, exceeding the accuracy and flexibility of full-custom designs. Based on a recently-proposed architecture for the emulation of a large-scale CNN universal machine, a new real-time video processing(More)