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Therapeutic peptides are highly potent and specific in their functions, but difficulties in their administration require parallel development of viable delivery systems to improve their bioavailability. In this study the potential of a novel lipid-based colloidal delivery system for improving the absorption of nasally and intestinally administered salmon(More)
An international Key Comparison of (177)Lu has recently been carried out. Twelve laboratories performed assays for radioactivity content on aliquots of a common master solution of (177)Lu, leading to eleven results submitted for entry into the Key Comparison Database of the Mutual Recognition Arrangement. A proposed Comparison Reference Value (CRV) was(More)
Twenty years ago South Africa's Radioactivity Standards Laboratory (now operated by the NMISA) was the first to measure the activity of (55)Fe by combining the triple-to-double coincidence ratio (TDCR) liquid scintillation method with theoretical efficiency formulae. The extracted activity was however found to be consistently low by about 6%. Due to(More)
This paper reports on absolute measurements made at the NMISA by the 4π[LS]β-γ coincidence extrapolation technique, which formed part of a key comparison of activity measurements of the radionuclide lutetium-177, a beta-gamma emitter. A detection efficiency analysis based on the decay scheme indicated that the coincidence extrapolation method is feasible(More)
The NMISA participated in the international key comparison of the pure beta-emitter Technetium-99, CCRI(II)-K2.Tc-99. The comparison solution was standardized using three methods, namely the TDCR efficiency calculation method, the CIEMAT/NIST efficiency tracing method and the 4π(LS)β-γ coincidence tracing method with Co-60 as tracer. Excellent agreement(More)
This paper reports on absolute activity measurements of iron-59 made at the National Metrology Institute of South Africa (NMISA) via 4π(LS)β-γ coincidence counting. The exercise formed part of an Asia Pacific Metrology Program (APMP) regional key comparison. Source data were analysed by the extrapolation technique for a number of gamma-ray window settings.(More)
The radionuclides 99mTc and 57Co were standardized via absolute liquid scintillation counting techniques. We provide the first technical report on the absolute standardization of 99mTc using 4π(LS)e-γ coincidence counting. The low detection efficiency of low-energy conversion electrons translates into a large efficiency extrapolation range. A simulation(More)