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A Peroxygenase from Chaetomium globosum Catalyzes the Selective Oxygenation of Testosterone
Unspecific peroxygenases (UPO, EC 1.11.2.1) secreted by fungi open an efficient way to selectively oxyfunctionalize diverse organic substrates, including less‐activated hydrocarbons, by transferringExpand
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From Alkanes to Carboxylic Acids: Terminal Oxygenation by a Fungal Peroxygenase.
A new heme-thiolate peroxidase catalyzes the hydroxylation of n-alkanes at the terminal position-a challenging reaction in organic chemistry-with H2 O2 as the only cosubstrate. Besides the primaryExpand
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Selective synthesis of the resveratrol analogue 4,4′-dihydroxy-trans-stilbene and stilbenoids modification by fungal peroxygenases
This work gives first evidence that the unspecific peroxygenases (UPOs) from the basidiomycetes Agrocybe aegerita (AaeUPO), Coprinopsis cinerea (rCciUPO) and Marasmius rotula (MroUPO) are able toExpand
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One-pot synthesis of human metabolites of SAR548304 by fungal peroxygenases.
Unspecific peroxygenases (UPOs, EC 1.11.2.1) have proved to be stable oxygen-transferring biocatalysts for H2O2-dependent transformation of pharmaceuticals. We have applied UPOs in a drug developmentExpand
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Fatty Acid Chain Shortening by a Fungal Peroxygenase
Abstract A recently discovered peroxygenase from the fungus Marasmius rotula (MroUPO) is able to catalyze the progressive one‐carbon shortening of medium and long‐chain mono‐ and dicarboxylic acidsExpand
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Selective Epoxidation of Fatty Acids and Fatty Acid Methyl Esters by Fungal Peroxygenases
Recently discovered fungal unspecific peroxygenases from Marasmius rotula and Chaetomium globosum catalyze the epoxidation of unsaturated fatty acids (FA) and FA methyl esters (FAME), unlike theExpand
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Selective synthesis of 4-hydroxyisophorone and 4-ketoisophorone by fungal peroxygenases
The recently discovered unspecific peroxygenases (UPOs) from the ascomycetes Chaetomium globosum and Humicola insolens were capable of selectively hydroxylating isophorone to 4-hydroxyisophoroneExpand
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Singlet‐Oxygen Generation by Peroxidases and Peroxygenases for Chemoenzymatic Synthesis
Singlet oxygen is a reactive oxygen species undesired in living cells but a rare and valuable reagent in chemical synthesis. We present a fluorescence spectroscopic analysis of the singlet‐oxygenExpand
Process for the selective oxygenation of testosterone and testosterone-like steroids
The invention relates to a method for enzymatic selective introduction of oxygen into the backbone of preferably testosterone and testosterone-like steroids in a water-containing solvent in theExpand