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An external loop region of domain III of dengue virus type 2 envelope protein is involved in serotype-specific binding to mosquito but not mammalian cells.

• Jan-Jong Hung, Meng-Ti Hsieh, Ming-Jer Young, Chuan-Liang Kao, Chwan-Chuen King, Wen Chang
• Journal of virology
• 2004

Dengue virus (DV) is a flavivirus and infects mammalian cells through mosquito vectors. This study investigates the roles of domain III of DV type 2 envelope protein (EIII) in DV binding to the host… (More)

Sumoylation of specificity protein 1 augments its degradation by changing the localization and increasing the specificity protein 1 proteolytic process.

• Yi-Ting Wang, J F Chuang, M R Shen, W Yang, Wen-Chang Chang, Jan-Jong Hung
• Journal of molecular biology
• 2008

Although specificity protein 1 (Sp1) accumulation has been found in various tumor strains, its mechanism is still not very clear. Herein, we found that modification of Sp1 by SUMO-1 facilitates Sp1… (More)

Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis.

• J F Chuang, Yi-Ting Wang, Shiu-Hwa Yeh, Yi-Wen Liu, Wen-Chang Chang, Jan-Jong Hung
• Molecular biology of the cell
• 2008

The transcription factor Sp1 is ubiquitously expressed in different cells and thereby regulates the expression of genes involved in many cellular processes. This study reveals that Sp1 was… (More)

Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription.

• Jan-Jong Hung, Yi-Ting Wang, Wen-Chang Chang
• Molecular and cellular biology
• 2006

We previous reported that Sp1 recruits c-Jun to the promoter of the 12(S)-lipoxygenase gene in 12-myristate 13-acetate-treated cells. We now show that Sp1 that recruited HDAC1 to the Sp1/cJun complex… (More)

The sigma-1 receptor-zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury

• Tzu-Chieh Su, Shu-Hui Lin, +8 authors J F Chuang
• Neuropharmacology
• 2016

The accumulation of reactive oxygen species (ROS) have implicated the pathogenesis of several human diseases including neurodegenerative disorders, stroke, and traumatic brain injury, hence… (More)

Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells.

• J F Chuang, Chien-Hsing Wu, M D Lai, Wen-Chang Chang, Jan-Jong Hung
• International journal of cancer
• 2009

Numerous studies have documented that Sp1 expression level were elevated in various human cancers. However, the promoters of many pro-apoptotic genes have been found to contain the Sp1 binding… (More)

Interplay of posttranslational modifications in Sp1 mediates Sp1 stability during cell cycle progression.

• Yi-Ting Wang, W Yang, Wen-Chang Chang, Jan-Jong Hung
• Journal of molecular biology
• 2011

Although Sp1 is known to undergo posttranslational modifications such as phosphorylation, glycosylation, acetylation, sumoylation, and ubiquitination, little is known about the possible interplay… (More)

The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional…

• Che-Chia Hsu, Chang-Han Chen, +7 authors D L Lin
• Biochimica et biophysica acta
• 2014

58-kDa microspherule protein (MSP58) plays an important role in a variety of cellular processes including transcriptional regulation, cell proliferation and oncogenic transformation. Currently, the… (More)

Functional role of post-translational modifications of Sp1 in tumorigenesis

• wendy. chang, Jan-Jong Hung
• Journal of Biomedical Science
• 2012

Specific protein 1 (Sp1), the first transcription factor to be isolated, regulates the expression of numerous genes involved in cell proliferation, apoptosis, and differentiation. Recent studies… (More)

Molecular chaperone Hsp90 is important for vaccinia virus growth in cells.

• Jan-Jong Hung, C S Chung, Wen Chang
• Journal of virology
• 2002

Molecular chaperones assist protein folding, and some chaperones are induced by heat, nutrient depletion, or pathogen invasion. This study investigates the role played by Hsp90 in the life cycle of… (More)

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