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Many interesting but practically intractable problems can be reduced to that of finding the ground state of a system of interacting spins; however, finding such a ground state remains computationally difficult. It is believed that the ground state of some naturally occurring spin systems can be effectively attained through a process called quantum(More)
Alzheimer disease is characterized by extracellular plaques composed of Abeta peptides. We show here that these plaques also contain the serine protease inhibitor neuroserpin and that neuroserpin forms a 1:1 binary complex with the N-terminal or middle parts of the Abeta(1-42) peptide. This complex inactivates neuroserpin as an inhibitor of tissue(More)
Kinetic rate laws Following our previous analysis 19,26 , the generation of fibril mass, M, when both primary and secondary nucleation events occur is described by the integrated rate law: í µí±€(í µí±¡) í µí±€(∞) = 1 − � í µí°µ + + í µí° ¶ + í µí°µ + + í µí° ¶ + í µí±’ í µí¼…í µí¼… í µí°µ − + í µí° ¶ + í µí±’ í µí¼…í µí¼… í µí°µ − + í µí° ¶ + � í µí±˜ ∞ 2(More)
Nature's high-performance polymer, spider silk, consists of specific proteins, spidroins, with repetitive segments flanked by conserved non-repetitive domains. Spidroins are stored as a highly concentrated fluid dope. On silk formation, intermolecular interactions between repeat regions are established that provide strength and elasticity. How spiders(More)
Little is known about of how software embedded in complex industrial technical systems is maintained. In this paper, we identify industrial maintenance process steps and position software maintenance activities within them. We do this in the context of JAS 39 Gripen, a multi-role combat aircraft developed by Saab.
In Alzheimer's disease the amyloid beta-peptide (Abeta) aggregates in brain tissue and arteries. Abeta is proteolytically cleaved out from amyloid precursor protein (APP) by different secretases. Recently, the transmembrane protein ITM2B/Bri2, which is expressed in neurons and associated with familial British and Danish dementia, was shown to inhibit APP(More)
Bacterial growth in multicellular communities, or biofilms, offers many potential advantages over single-cell growth, including resistance to antimicrobial factors. Here we describe the interaction between the biofilm-promoting components curli fimbriae and cellulose of uropathogenic E. coli and the endogenous antimicrobial defense in the urinary tract. We(More)
BACKGROUND The BRICHOS domain has been found in 8 protein families with a wide range of functions and a variety of disease associations, such as respiratory distress syndrome, dementia and cancer. The domain itself is thought to have a chaperone function, and indeed three of the families are associated with amyloid formation, but its structure and many of(More)
BACKGROUND Esophageal squamous cell carcinoma (ESCC) is a genetically complex tumor type and a major cause of cancer related mortality. Although distinct genetic alterations have been linked to ESCC development and prognosis, the genetic alterations have not gained clinical applicability. We applied array-based comparative genomic hybridization (aCGH) to(More)