Jan J. Verstraete

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BACKGROUND To assess acute (primary endpoint) and late toxicity, quality of life (QOL), biochemical or clinical failure (secondary endpoints) of a hypofractionated IMRT schedule for prostate cancer (PC). METHODS 38 men with localized PC received 66 Gy (2.64 Gy) to prostate,2 Gy to seminal vesicles (50 Gy total) using IMRT.Acute toxicity was evaluated(More)
BACKGROUND AND PURPOSE Although intensity modulated radiation therapy is characterized by three-dimensional dose distributions which are often superior to those obtained with conventional treatment plans, its routine clinical implementation is partially held back by the complexity of the beam verification. This is even more so when a dynamic multileaf(More)
INTRODUCTION Intrafractional motion consists of two components: (1) the movement between the on-line repositioning procedure and the treatment start and (2) the movement during the treatment delivery. The goal of this study is to estimate this intrafractional movement of the prostate during prostate cancer radiotherapy. MATERIAL AND METHODS Twenty-seven(More)
The enormous developments in radiation technology open new horizons for improvements in local tumour control. However, the evolution from conventional external beam radiotherapy planning to conformal therapy might be hampered by the potential risk of over-reliance on the physician's capability of estimating the tumour extent from imaging modalities. The(More)
Time measurements were performed on daily treatment delivery with the aim to quantify the impact of quality assurance (QA) using an electronic portal imaging device (EPID) on RT delivery time and to validate the time burden of intensity modulated radiation therapy (IMRT) as an example of advanced technology. Both increased QA and the delivery of IMRT were(More)
This paper reports on an evaluation of 5 RapidArc optimization approaches vs IMRT. This study includes 11 patients with adenocarcinoma of the prostate. Rectal Normal Tissue Complication Probability is used as a constraint in a dose escalation. RapidArc rectal NTCP's are lower than those of IMRT (p = 0.007). This allows a mean dose escalation of 2.1 Gy([0.7(More)
Due to the large number of steps and the number of persons involved in the preparation of a radiation treatment, the transfer of information from one step to the next is a very critical point. Errors due to inadequate transfer of information will be reflected in every next step and can seriously affect the final result of the treatment. We studied the(More)
PURPOSE To quantify changes in radiotherapy costs occurring in a decade of medical-technological evolution. MATERIALS AND METHODS The activity-based costing (ABC) model of the University Hospitals Leuven (UHL) radiotherapy (RT) department was adapted to current RT standards. It allocated actual resource costs to the treatments based on the departmental(More)
A new method for feedstock reconstruction of industrially important hydrocarbon fractions is developed using as input the analytically determined commercial indices such as the average molecular weight, the specific density, the H/C-ratio, the paraffin, isoparaffin, olefins, naphthenes, aromatics (PIONA) weight fractions and a set of ASTM boiling points.(More)
BACKGROUND AND PURPOSE Currently, most available patient alignment tools based on implanted markers use manual marker matching and rigid registration transformations to measure the needed translational shifts. To quantify the particular effect of prostate gland shrinkage, implanted gold markers were tracked during a course of radiotherapy including an(More)