Jan J B Du Plessis

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This study was designed to determine the factors predicting the post-race rectal temperature in marathon runners. Post-race rectal temperatures of 30 recreational runners (maximum oxygen consumption (VO2max) = 58.3 +/- 5.9 ml O2.kg-1.min-1; mean +/- SD) who completed a 42.2 km marathon at 75.8% (+/- 9.3%) VO2max were measured and related to their levels of(More)
UNLABELLED A third national children's oral health survey was conducted in South Africa between July 1999 and June 2002. OBJECTIVE AND METHODOLOGY One of the objectives of the survey was to determine the prevalence and severity of dental caries and the treatment needs for dental caries in 4- to 5-, 6-, 12- and 15-year-old South African school children.(More)
INTRODUCTION Early Childhood Caries (ECC) can be defined as dental caries in preschool children. There is a lack of data on the prevalence of ECC at a global, national, regional and district level. Hence the severity and extent of the disease is unknown. OBJECTIVES The purpose of the study was to establish the prevalence of ECC among 3- to 5-year-old(More)
Because isoniazid is a selective inducer of CYP2E1 and isoniazid-induced hepatotoxicity is believed to be due to activation of its metabolites by CYP450, this study was undertaken to determine the effect of isoniazid containing regimen on CYP2E1 in TB-patients. The activity of CYP2E1 in 11 newly diagnosed TB-patients (5 F, 6 M) was investigated before (day(More)
The National Oral Health Survey showed that differences in the prevalence and experience of dental caries occurred between racial groups and between geographical areas according to fluoride levels in the domestic water supply that varied from <0.05 ppm in the coastal areas to 0.35 ppm in the Bloemfontein area. The Orange Free State (OFS) Goldfields were not(More)
The extent of uptake of gamma interferon (gamma-IFN) in various strata of hairless mouse, human and hamster skin upon application of a liposomal formulation and an aqueous solution were determined by in vitro diffusion cell experiments. For each of the animal species studied, 70-80% of the liposomally entrapped IFN was deposited onto or penetrated into the(More)
This study was undertaken to investigate the effect of co-administration of valproic acid and acyclovir on the pharmacokinetic parameters of each other. Fifteen white New Zealand rabbits were divided into three groups: A, B and C. Group A received acyclovir only, group B received valproic acid only and group C received a combination of acyclovir and(More)
INTRODUCTION The identification of a rural village with a very low incidence of dental caries among the children provided the opportunity to study the diets of children apparently not exposed to risk factors for dental caries and compare them with children who were at risk. OBJECTIVE To compare the diet, nutritional status and dental caries experience of(More)
The aim of this study was to illustrate the initial subclinical drug-induced liver injury and the associated adaptive immune response by monitoring for the changes in plasma IL-2, IL-10, and some cytochrome P450 activity during chronic administration of nevirapine (NVP), isoniazid (INH), and paracetamol (PAR) in rats without clinical hepatotoxicity. Male(More)