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Several serotonergic drugs were tested in isolation-induced aggressive behavior in male mice using ethological methodology. Eltoprazine, a mixed 5-HT1 agonist, reduced aggression but enhanced social interest and exploration. Several 5-HT1A agonists (8-OH-DPAT, ipsapirone, buspirone, 5-Me-ODMT) and a 5-HT uptake blocker (fluvoxamine) also reduced aggression.(More)
Fifty-one pigs were fed a low-cholesterol basal diet, to which either 10% (by weight) of lard fat (group INORM, n = 7), 2% cholesterol plus 8% lard fat (group II, n = 33), or 2% cholesterol plus 4% lard fat plus 4% fish oil (group IIIPREV, n = 11) was added. In all pigs, the left anterior descending coronary artery and the abdominal aorta were denuded at 1(More)
To investigate the effects of fish oil nutrition on cardiac haemodynamics and the biochemical response to ischaemia-reperfusion, young pigs (5 weeks old) were fed a 9% lard fat diet or a mixed diet of 4.5% mackerel oil and 4.5% lard fat for 16 weeks. In the mackerel oil fed pigs plasma cholesterol and triglyceride levels decreased by 22% and 58% (both p(More)
Fish-oil nutrition leads to a change in fatty acid composition of cellular membranes. To investigate whether this affects cardiac responses to acute myocardial ischemia, pigs were fed a 9.1% (w/w) mackerel-oil (n=8) or 9.1% (w/w) lard-fat diet (n=8). Eight weeks mackerel-oil feeding reduced plasmacholesterol (51%) and triglyceride (48%), while the n-6 fatty(More)
It is widely recognized that dietary polyunsaturated fatty acids (PUFA's) and cholesterol can profoundly influence the development of atherosclerotic plaques in coronary vessels, which may lead to myocardial infarction. The possibility that dietary fatty acids may also directly influence cardiac function has received less attention. We therefore reviewed(More)
In doses of 0.5 to 3.0 mg/kg bevantolol caused dose-dependent decreases in cardiac output (10% to 35%), primarily due to negative chronotropic actions, as heart rate decreased by 10% to 25%. Stroke volume decreased after the highest dose (15%), due to a negative inotropic action (maximum left ventricular dP/dt decreased by 40%) and a mild vasoconstriction(More)
The influence of substitution of eicosapentanoic acid to the diet has been investigated in juvenile domestic pigs (7-8 kg) fed either a mixture of 4.5% (wt/wt) mackerel oil and 4.5% (wt/wt) lard fat (n = 12, ML group) or a 9% (wt/wt) lard fat (n = 12, L group) diet for 16 wk. Plasma triglyceride and total cholesterol did not change in L, but had decreased(More)
The effects of the imidazo-pyridine AR-L 115 BS on global and regional myocardial function were investigated in anesthetized pigs in the absence and in the presence of the bradycardiac action of alinidine. AR-L 115 BS (0.1–0.8 mg·kg−1·min−1) increased myocardial contractility (up to 75%) and reduced preload (50%) and afterload (50%) in a dose-dependent(More)
Intracoronary infusion of low doses (0.1–0.3 μg·kg−1) of nifedipine caused dose-dependent decreases in regional myocardial O2-consumption, without significant changes in any of its major global hemodynamic determinants: heart rate, left ventricular systolic and end-diastolic pressure and maxLVdP/dt. Futhermore, regional myocardial function was unaltered. It(More)
The cardiovascular effects of the pyridazinone-derivatives pimobendan and its O-demethylmetabolite UD-CG 212 Cl (2-(4-hydroxy-phenyl)-5-(5-methyl-3-oxo-4,5-dihydro-2H-6-pyridazinyl) benzimidazole HCl) were studied in conscious pigs, employing consecutive intravenous 10 min infusions of 10, 25, 50 and 100 micrograms kg-1 min-1 and 2, 4 and 8 micrograms kg-1(More)