Jan H P van der Meulen

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CONTEXT The literature contains a large number of potential biases in the evaluation of diagnostic tests. Strict application of appropriate methodological criteria would invalidate the clinical application of most study results. OBJECTIVE To empirically determine the quantitative effect of study design shortcomings on estimates of diagnostic accuracy. (More)
OBJECTIVE To determine whether the variation in unadjusted rates of caesarean section derived from routine data in NHS trusts in England can be explained by maternal characteristics and clinical risk factors. DESIGN A cross sectional analysis using routinely collected hospital episode statistics was performed. A multiple logistic regression model was used(More)
OBJECTIVES This study summarises the results of a National Audit of sino-nasal surgery carried out in England and Wales. It describes patient and operative characteristics as well as patient outcomes up to 36 months after surgery. DESIGN Prospective cohort study. SETTING NHS hospitals in England and Wales. PARTICIPANTS Consecutive patients undergoing(More)
BACKGROUND Multiparametric magnetic resonance imaging (mpMRI) may have a role in detecting clinically significant prostate cancer in men with raised serum prostate-specific antigen levels. Variations in technique and the interpretation of images have contributed to inconsistency in its reported performance characteristics. OBJECTIVE Our aim was to make(More)
BACKGROUND It was shown that men who were conceived during the Dutch famine of 1944-1945 had higher rates of obesity at age 19 y than those conceived before or after it. OBJECTIVE Our objective was to study the effects of prenatal exposure to the Dutch famine on obesity in women and men at age 50 y. DESIGN We measured the body size of 741 people born at(More)
OBJECTIVE To describe the trends of severe perineal tears in England and to investigate to what extent the changes in related risk factors could explain the observed trends. DESIGN A retrospective cohort study of singleton deliveries from a national administrative database. SETTING The English National Health Service between 1 April 2000 and 31 March(More)
OBJECTIVES To describe the reliability and validity of the Postoperative Morbidity Survey (POMS). To describe the level and pattern of short-term postoperative morbidity after major elective surgery using the POMS. STUDY DESIGN AND SETTING This was a prospective cohort study of 439 adults undergoing major elective surgery in a UK teaching hospital. The(More)
BACKGROUND Although localised prostate cancer is multifocal in most instances, the index lesion might be responsible for disease progression. OBJECTIVE To determine the early genitourinary functional and cancer control outcomes of index lesion ablation. DESIGN, SETTING, AND PARTICIPANTS This was a single-centre prospective development study in which 56(More)
OBJECTIVE The objective of this study was to determine the rate of complications of surgery for nasal polyposis and chronic rhinosinusitis as well as their risk factors. STUDY DESIGN, SETTING, PARTICIPANTS, AND OUTCOME MEASURES: The authors conducted a prospective study of 3,128 patients who underwent sinonasal surgery during 2000 and 2001 in 87 National(More)