Jan-H Baumert

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BACKGROUND In this study we investigated the effects of the physical properties of xenon on respiratory mechanisms in pigs. METHODS With institutional approval, 10 female pigs (mean 25.2 (SD 2.5) kg) were anaesthetized with thiopental, remifentanil, and pancuronium. Gas flow and pressure were recorded continuously at the proximal end of the tracheal tube(More)
BACKGROUND Right ventricular (RV) function is an important determinant of survival after myocardial infarction. The efficacy of reperfusion therapy might be increased by the cardioprotective action of inotropic agents, which are used for symptomatic therapy in situations with compromised hemodynamics. Therefore, we used a porcine model of RV ischemia and(More)
BACKGROUND Postoperative cognitive impairment after general anaesthesia, especially in the elderly, is a well-recognized problem. Xenon, known to be an N-methyl-d-aspartate antagonist, may be advantageous. In this study, the early cognitive function in the elderly after general anaesthesia with xenon was compared with that after desflurane. METHODS After(More)
BACKGROUND The minimum alveolar concentration (MAC) is a traditional index of the hypnotic potency of an inhalational anaesthetic. To investigate the anaesthetic as well as the unwanted effects of xenon (Xe) in a swine model, it is useful to know MAC(Xe). METHODS The study was performed using ten swine (weight 27.8-35.4 kg) anaesthetized with halothane(More)
BACKGROUND Partial liquid ventilation (PLV) and prone position can improve arterial oxygen tension (PaO2) in acute lung injury (ALI). The authors evaluated additive effects of these techniques in a saline lung lavage model of ALI. METHODS ALI was induced in 20 medium-sized pigs (29.2+/-2.5 kg body weight). Gas exchange and hemodynamic parameters were(More)
BACKGROUND The hypothesis that xenon anaesthesia provided haemodynamic stability was tested in patients with heart failure in a prospective, randomized, single-blind design. METHODS Twenty-six patients scheduled for implantation of a cardioverter-defibrillator (ICD) received xenon 60-65% in oxygen (xenon group, n = 12) or propofol 3 mg/kg/h (propofol(More)
BACKGROUND There is limited clinical experience with xenon in a large number of patients. We present intra- and postoperative haemodynamic and recovery data comparing xenon and total intravenous anaesthesia with propofol. METHODS A total of 160 patients aged 18-60 years (ASA I and II) undergoing elective surgery took part in this prospective non-blinded(More)
OBJECTIVES To investigate if the protective effects of xenon and isoflurane against myocardial ischemia-reperfusion damage would be additive. DESIGN A prospective, randomized laboratory investigation. SETTING An animal laboratory of a university hospital. PARTICIPANTS Thirty-six pigs (female German landrace). INTERVENTIONS In an open-chest(More)
BACKGROUND In contrast to humans, young pigs naturally have a low COPpl (12-16 mmHg versus 22-26 mmHg in young humans). Thus, behavior occurring when volume management is performed similar to human medicine might be different. Potentially underestimated intra- to extravascular fluid and solute shifts could influence time course of variables investigated.(More)
BACKGROUND Right ventricular (RV) function is an important determinant of post-operative outcome. Consequences of RV infarction might be limited by pre-conditioning with volatile anesthetic drugs. Therefore, we used a porcine model of RV ischemia and reperfusion (IR) injury to study the influence of isoflurane and xenon on the extent and degree of(More)