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  • Nicola J Hewitt, María José Gómez Lechón, +13 authors Jan G. Hengstler
  • Biology, Medicine
  • Drug metabolism reviews
  • 2007 (First Publication: 1 January 2007)
  • This review brings you up-to-date with the hepatocyte research on: 1) in vitro–in vivo correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross-talk using humanContinue Reading
  • Patricio Godoy, Nicola J Hewitt, +90 authors Jan G. Hengstler
  • Medicine, Biology
  • Archives of Toxicology
  • 2013 (First Publication: 1 August 2013)
  • This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules,Continue Reading
  • Johan Botling, Karolina Edlund, +15 authors Patrick Micke
  • Medicine, Biology
  • Clinical Cancer Research
  • 2012 (First Publication: 2 October 2012)
  • Purpose: Global gene expression profiling has been widely used in lung cancer research to identify clinically relevant molecular subtypes as well as to predict prognosis and therapy response. So far,Continue Reading
  • Werner Lilienblum, Wolfgang Dekant, +6 authors K.-M. Wollin
  • Chemistry, Medicine
  • Archives of Toxicology
  • 2008 (First Publication: 1 April 2008)
  • During the last two decades, substantial efforts have been made towards the development and international acceptance of alternative methods to safety studies using laboratory animals. In the EU,Continue Reading
  • Juergen Dr Fuchs, Jan G. Hengstler, Gerd Boettler Franz Oesch
  • Medicine
  • International archives of occupational and…
  • 1996 (First Publication: 1 March 1996)
  • The genotoxic effect of occupational exposure to bitumen-based products was determined by the extent of DNA strand breaks and alkali-labile sites of the DNA of peripheral mononuclear blood cells fromContinue Reading