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  • C. S. Higano, Jordan D. Berlin, +6 authors J. M. Mehnert
  • Medicine
  • Investigational New Drugs
  • 2015 (First Publication: 1 April 2015)
  • SummaryBackground: Type 1 insulin-like growth factor receptor (IGF-IR) signaling is often dysregulated in cancer. Cixutumumab, a fully human IgG1 monoclonal antibody, blocks IGF-IR and inhibitsContinue Reading
  • Jin Gao, Frans van Roy, +5 authors Marcus Mareel
  • Biology, Medicine
  • Pathology, research and practice
  • 1987 (First Publication: 1 February 1987)
  • Fischer rat cells before and after transfection with immortalizing and transforming genes produced tumours after s.c., i.p., or i.v. injection of cell suspensions and after s.c. implantation ofContinue Reading
  • David E Gerber, Toby Christopher Campbell, +6 authors Maria Q. Baggstrom
  • Medicine
  • 2014 (First Publication: 20 May 2014)
  • 8050 Background: In NSCLC, the PDGF-PDGFR axis mediates angiogenesis, local invasion, and tumor interstitial pressure. Olaratumab (IMC-3G3), a fully human monoclonal antibody, selectively binds humanContinue Reading