Jan Alexis Nielsen

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This study reports on the findings from a WHO sponsored cross-national investigation of life events and schizophrenia. Data are presented from a series of 386 acutely ill schizophrenic patients selected from nine field research centers located in developing and developed countries (Aarhus, Denmark; Agra, India; Cali, Colombia; Chandigarh, India; Honolulu,(More)
9-Amino-1,2,3,4-tetrahydroacridine (THA) has been reported to cause improvement in patients with senile dementia of the Alzheimer's type. We have examined some effects of THA in vitro and in vivo to define its mechanism of action. In vitro, THA inhibits acetylcholinesterase (AChE) (IC50 = 223 nM) and blocks [3H]AFDX-116 (M2) and [3H]telenzepine (M1) binding(More)
The purpose of the present study was to determine the effects of low-level formaldehyde exposure upon behavior and neurochemistry in the male rat. Rats were exposed to either air or formaldehyde vapor (5, 10 or 20 parts per million) for 3 hours on 2 consecutive days during which behavioral observations were made. Following the second exposure session the(More)
The purpose of the present study was to compare (-)-cathinone and its analogue (+/-)-cathinone using behavioral and neurochemical measures. Rats were trained to discriminate between 0.6 mg/kg (-)- or (+/-)-cathinone and saline in a food-motivated, two-lever operant task. In addition, concentrations of dopamine, norepinephrine, 5-hydroxytryptamine and their(More)
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