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Estrogen receptor (ER) , a modulator of ER in the uterus
Many of the effects of estrogens on the uterus are mediated by ERα, the predominant ER in the mature organ. Because of the poor reproductive capacity of ERβ knockout (BERKO) female mice (small litterExpand
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A role for estrogen receptor β in the regulation of growth of the ventral prostate
In normal rats and mice, immunostaining with specific antibodies revealed that nuclei of most prostatic epithelial cells harbor estrogen receptor β (ERβ). In rat ventral prostate, 530- and 549-aaExpand
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The Anti-estrogenic Effect of All-trans-retinoic Acid on the Breast Cancer Cell Line MCF-7 Is Dependent on HES-1 Expression*
All-trans-retinoic acid has been shown to have an antiproliferative effect in the estrogen receptor α-positive breast cancer cell line MCF-7. The mechanism of this effect is not well understood. WeExpand
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From the Cover: Abolition of male sexual behaviors in mice lacking estrogen receptors α and β (αβERKO)
Male mice with a knockout of the estrogen receptor (ER)-α gene, a ligand-activated transcription factor, showed reduced levels of intromissions and no ejaculations whereas simple mounting behaviorExpand
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Acyl-CoA Esters Antagonize the Effects of Ligands on Peroxisome Proliferator-activated Receptor α Conformation, DNA Binding, and Interaction with Co-factors*
The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor and a key regulator of lipid homeostasis. Numerous fatty acids and eicosanoids serve as ligands andExpand
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Quantitative Proteomics and Transcriptomics Addressing the Estrogen Receptor Subtype-mediated Effects in T47D Breast Cancer Cells Exposed to the Phytoestrogen Genistein*
The present study addresses, by transcriptomics and quantitative stable isotope labeling by amino acids in cell culture (SILAC)-based proteomics, the estrogen receptor α (ERα) and β (ERβ)-mediatedExpand
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Characteristics and Function of the Novel Estrogen Receptor β
Publisher Summary This chapter explains the influence that estrogen has on growth, differentiation, and functioning of many target tissues, which also includes tissues of the male and femaleExpand
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Chapter 9 Molecular aspects of steroid receptor/DNA binding
Publisher Summary This chapter presents the molecular aspects of steroid receptor/DNA binding. The general principles used by transcription factors, and specifically steroid receptors, to accomplishExpand