Jamie Woodcock

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Psoriasis and psoriatic arthritis are immune disorders with a complex polygenic basis. HLA-Cw6, which lies in the major histocompatibility region on chromosome 6, is considered the major genetic determinant of psoriasis. Recent genome-wide association studies have identified new variants outside of the MHC with relevance to the immunology of psoriasis.(More)
BACKGROUND The Psoriasis Area and Severity Index (PASI) is considered the gold standard assessment tool for psoriasis severity, but PASI is limited by its complexity and insensitivity in people with mild psoriasis. OBJECTIVE We sought to evaluate the product of a Physician Global Assessment (PGA) and Body Surface Area (BSA) (PGAxBSA) as an alternative to(More)
Sucrose has been found to decrease the fluorescence observed during the standard fluorometric assay of tryptophan. The quenching is enhanced with increasing concentrations of sucrose. This phenomenon is not due to a metal contaminant in the sucrose, nor to a direct interaction of the sugar with the fluorophore, norharman, which results from the oxidation of(More)
Changes in severity of psoriasis and psoriatic arthritis (PsA) are assessed in clinical trials by a variety of physical examination instruments. At the 2010 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), members were updated on the development and availability of modules that teach these instruments.(More)
INTRODUCTION Actinic granuloma is a granulomatous reaction resulting from longstanding sun damage to the dermis. It is described clinically by the appearance of flesh-colored or pink papules, which classically coalesce into annular lesions. Diagnosis is typically made histopathologically, with findings of granulomatous inflammation associated with(More)
Fig 1. Giant pilomatricoma. An 18-year-old Hispanic man with an 8-cm 3 9-cm firm, exophytic, pedunculated, reddish tumor with punctate ulcerations and yellow serous drainage on the anterior aspect of the chest. CASE REPORT On presentation, the patient had an 8-cm 3 9-cm firm, exophytic, pedunculated, reddish tumor with punctate ulcerations, yellow serous(More)
Fig 1. Photo-distributed eruption in a patient on simeprevir. The patient presented with a large erosion of the lower vermilion with honey-colored and hemorrhagic crusting (A) and ill-defined erythematous plaques with overlying tense bullae on the dorsolateral hands (B). INTRODUCTION Recently there has been a rapid evolution in the treatment of hepatitis C(More)
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