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Chemotherapies, HIV infections, and treatments to block organ transplant rejection are creating a population of immunocompromised individuals at serious risk of systemic fungal infections. Since single-agent therapies are susceptible to failure due to either inherent or acquired resistance, alternative therapeutic approaches such as multi-agent therapies… (More)
Monitoring of 140 patients after hip-replacement arthroplasty using both impedance plethysmography and 125I fibrinogen scanning of the lower extremities showed that half had no evidence of thrombosis, one-quarter had moderate or extensive thrombosis, and one-quarter had abnormal scans only. In the patients with only abnormal scans the process appeared to… (More)
Complete asymmetric amplification of ethylenediammonium sulfate was achieved under continuous dissolution/crystallization conditions using an abrasion/grinding method.
Spontaneous asymmetric generation of supramolecular chiral fibers was observed in the folding induced self-assembly of a lock-washer shaped foldamer. A secondary nucleation growth mechanism is proposed to explain the observed chiral amplification or deracemization of these supramolecular fibers.
In a random double-blind trial monitored by 125I-fibrinogen leg scan, impedance plethysmography, and contrast phleobograms if impedance became abnormal, hydroxycholoroquine was shown to be no more effective than placebo for prevention of venous thrombosis after total hip replacement. Subsequently, the combination of hydroxychloroquine with aspirin was shown… (More)