Jamie Steidl

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Kv1.2 and Kv1.5 are two subtypes of voltage-gated potassium channels expressed in heart that are thought to contribute to phase 1 (ITO) and phase 3 (IK) components of cardiac action potential repolarization. Although the effect of decreased pH in prolonging cardiac action potentials is well documented, the molecular target of acidification has not(More)
The rapidly inactivating A-type K+ current (IA) is prominent in hippocampal neurons; and the speed of its inactivation may regulate electrical excitability. The auxiliary K+ channel subunit Kvbeta 1.1 confers fast inactivation to Shaker-related channels and is postulated to affect IA. Whole-cell patch clamp recordings of rat hippocampal pyramidal neurons in(More)
The quaternary ammonium compound clofilium and its tertiary amine derivative LY97241 were used to analyze mechanisms of block in a voltage-gated potassium channel. Wild-type and mutant Kv1.5 channels expressed in Xenopus oocytes were recorded by two-electrode voltage clamp. Open-channel block to 20% of the control current amplitude was induced reversibly by(More)
The 2012 Brawley earthquake swarm occurred in the Brawley Seismic Zone (BSZ) within the Imperial Valley of southern California (Fig. 1). The BSZ is the northernmost extensional segment of the Pacific–North America plate boundary system. Johnson and Hill (1982) used the distribution of seismicity since the 1930s to outline the geographical extent of the BSZ,(More)
The use of carbon-fibre-reinforced polymers (CFRP) laminates in structural applications where high strength-to-weight and high stiffness-to-weight ratios are required is wellestablished. However, because of structural distortions induced by moisture absorption effects, polymer matrix composites are not yet definitely considered suitable candidate for(More)
The aim of the present work is to demonstrate of the influence of the adventitia on distribution of residual stresses in the human aorta. The biomaterial increase in media as well as in adventitia in the course of the aorta's growth is formed by an intussusceptive mechanism of growth. In children's aortas, formative elastin lamellae are wavy with high(More)
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