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BACKGROUND Attention-deficit/hyperactivity disorder (ADHD) is often treated using methylphenidate, a psychostimulant that inhibits the dopamine transporter. This led E.H. Cook and colleagues to consider the dopamine transporter locus (DAT1) as a primary candidate gene for ADHD. That group reported a significant association between ADHD and the 480-base pair(More)
The adrenergic system plays a known role in attentional systems and a suspected causal role in attention-deficit hyperactivity disorder (ADHD), based on evidence from pharmacological interventions and animal models. The efficacy of the highly selective noradrenergic reuptake inhibitor, tomoxetine, in treating ADHD symptoms supports the system's role in ADHD(More)
INTRODUCTION The objective of this study was to determine if preoperative warming up by obstetrics and gynecology trainees, using a validated bench model for intracorporeal suturing, improves efficiency, precision, and quality of laparoscopic suturing. METHODS A randomized crossover design was used. Fourteen obstetrics and gynecology residents were(More)
OBJECTIVE We evaluated the inter-rater reliability (IRR) of assessing the quality of evidence (QoE) using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. STUDY DESIGN AND SETTING On completing two training exercises, participants worked independently as individual raters to assess the QoE of 16 outcomes. After(More)
OBJECTIVE To estimate the effect of energy-based vessel sealing compared with suturing in women undergoing vaginal hysterectomy with respect to surgical outcomes. DATA SOURCES We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE. We also screened references from relevant articles and searched trial registries and other(More)
OBJECTIVES To understand current laparoscopic entry practices among Canadian gynaecologists and to raise awareness of patient safety in accordance with the Society of Obstetricians and Gynaecologists of Canada clinical practice guideline, "Laparoscopic Entry: A Review of Techniques, Technologies, and Complications," published in May 2007. METHODS A(More)
OBJECTIVE To estimate the clinical and economic effect of using second-generation endometrial ablation devices compared to first-generation devices for treatment of menorrhagia in pre-menopausal women. The secondary objective was to compare the second-generation devices with one another. DATA SOURCES We searched Medline and EMBASE, and other sources of(More)
OBJECTIVE To estimate the benefits and harms of misoprostol use for cervical dilation in patients undergoing operative hysteroscopy. DATA SOURCES We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials (from inception to February 2011). We also searched trial registries, other sources of unpublished or gray literature, and the(More)
OBJECTIVES To determine the safety and efficacy of a novel regimen of transdermal estrogen and vaginally administered progesterone for treatment of menopausal symptoms. STUDY METHODS A retrospective chart review was conducted of menopausal patients aged 46-65, using an oestradiol patch and vaginally administered prometrium for at least 1 year. Available(More)