Jamie I. MacPherson

Learn More
Human immunodeficiency virus type 1 (HIV-1) exploits a diverse array of host cell functions in order to replicate. This is mediated through a network of virus-host interactions. A variety of recent studies have catalogued this information. In particular the HIV-1, Human Protein Interaction Database (HHPID) has provided a unique depth of protein interaction(More)
With increased availability of satellite data products used in mapping surface energy balance and evapotranspiration (ET), routine ET monitoring at large scales is becoming more feasible. Daily satellite coverage is available, but an essential model input, surface temperature, is at 1 km or greater pixel resolution. At such coarse spatial resolutions, the(More)
A common method for presenting and studying biological interaction networks is visualization. Software tools can enhance our ability to explore network visualizations and improve our understanding of biological systems, particularly when these tools offer analysis capabilities. However, most published network visualizations are static representations that(More)
UNLABELLED BACKGROUND The processing of a microRNA results in an intermediate duplex of two potential mature products that derive from the two arms (5' and 3') of the precursor hairpin. It is often suggested that one of the sequences is degraded and the other is incorporated into the RNA-induced silencing complex. However, both precursor arms may give(More)
Large-scale molecular interaction data sets have the potential to provide a comprehensive, system-wide understanding of biological function. Although individual molecules can be promiscuous in terms of their contribution to function, molecular functions emerge from the specific interactions of molecules giving rise to modular organisation. As functions(More)
Hepatitis C virus (HCV) is a global problem. To better understand HCV infection researchers employ in vitro HCV cell-culture (HCVcc) systems that use Huh-7 derived hepatoma cells that are particularly permissive to HCV infection. A variety of hyper-permissive cells have been subcloned for this purpose. In addition, subclones of Huh-7 which have evolved(More)
This study examines the spatial variability of ozone fluxes over fiat heterogeneous terrain consisting of a patchwork of irrigated and nonirrigated surfaces. Fluxes of ozone and other quantities are computed from eight sequential flight legs of the Canadian Twin Otter research aircraft over the same track at 33 m above the surface for each of 2 days. The(More)
  • 1