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- Publications
- Influence
Recommended protocol for the Syrian hamster embryo (SHE) cell transformation assay.
- Marie-Aline Maire, K. Pant, +9 authors P. Vasseur
- Biology, Medicine
- Mutation research
- 11 April 2012
The Syrian hamster embryo (SHE) cell transformation assay (CTA) is a short-term in vitro assay recommended as an alternative method for testing the carcinogenic potential of chemicals. SHE cells are… Expand
Assessment of genotoxicity induced by 7,12‐dimethylbenz(a)anthracene or diethylnitrosamine in the Pig‐a, micronucleus and Comet assays integrated into 28‐day repeat dose studies
- J. Shi, L. Krsmanovic, +9 authors S. Springer
- Biology, Medicine
- Environmental and molecular mutagenesis
- 1 December 2011
As part of the Stage 3 of the Pig‐a international trial, we evaluated 7,12‐dimethylbenz(a)anthracene (DMBA) for induction of Pig‐a gene mutation using a 28‐day repeat dose study design in… Expand
Photo catalogue for the classification of cell colonies in the Syrian hamster embryo (SHE) cell transformation assay at pH 6.7.
- Susanne Bohnenberger, S. Bruce, +5 authors A. Poth
- Biology, Medicine
- Mutation research
- 11 April 2012
This catalogue is a display of Syrian hamster embryo (SHE) cell colony photos representative of the cell transformation assay (CTA) carried out at pH 6.7. It is intended as a visual aid for the… Expand
Prevalidation study of the Syrian hamster embryo (SHE) cell transformation assay at pH 6.7 for assessment of carcinogenic potential of chemicals.
- K. Pant, S. Bruce, +6 authors Karl-Rainer Schwind
- Medicine
- Mutation research
- 11 April 2012
The Syrian hamster embryo (SHE) cell transformation assay (CTA) is an important in vitro method that is highly predictive of rodent carcinogenicity. It is a key method for reducing animal usage for… Expand
An international validation study of a Bhas 42 cell transformation assay for the prediction of chemical carcinogenicity.
The Bhas 42 cell transformation assay is a sensitive short-term system for predicting chemical carcinogenicity. Bhas 42 cells were established from BALB/c 3T3 cells by the transfection of v-Ha-ras… Expand
Syrian hamster embryo (SHE) cell transformation assay with conditioned media (without X-ray irradiated feeder layer) using 2,4-diaminotoluene, 2,6-diaminotoluene and chloral hydrate.
- K. Pant, Jamie E. Sly, S. Bruce, C. Leung, R. San
- Biology, Medicine
- Mutation research
- 31 July 2008
The Syrian hamster embryo (SHE) cell transformation assay has traditionally been conducted with a feeder layer of X-ray irradiated cells to provide growth support to the target cells seeded in low… Expand
Syrian Hamster Embryo (SHE) cell transformation assay with and without X-ray irradiation of feeder cells using Di(2-ethylhexyl)phthalate (DEHP) and N-nitroso-N-methylnitroguanidine (MNNG).
- K. Pant, Jamie E. Sly, S. Bruce, A. Scott, P. Carmichael, R. San
- Chemistry, Medicine
- Mutation research
- 30 April 2010
The SHE cell transformation assay has traditionally been conducted with a feeder layer of X-ray irradiated cells to provide growth support to the target cells seeded in low numbers. The need for an… Expand
Combination comet/micronucleus assay validation performed by BioReliance under the JaCVAM initiative.
- K. Pant, L. Krsmanovic, +10 authors M. Aardema
- Biology, Medicine
- Mutation research. Genetic toxicology and…
- 1 July 2015
In the international validation study of the in vivo rat alkaline comet assay (comet assay), the Japanese Center for the Validation of Alternative Methods (JaCVAM) provided three coded chemicals to… Expand
Bacterial mutagenicity assays: Vehicle and positive control results from the standard Ames assay, the 6‐ and 24‐well miniaturized plate incorporation assays and the Ames II™ assay
- K. Pant, S. Bruce, +8 authors Rohan Kulkarni
- Medicine, Biology
- Environmental and molecular mutagenesis
- 1 July 2016
Bacterial mutation assays are conducted routinely as part of the safety assessment of new chemicals. The OECD Test Guideline (TG) 471 describes the conduct of the standard agar plate Ames assay,… Expand