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  • Jing Shi, Ljubica Krsmanovic, +9 authors Sandra A. Springer
  • Biology, Medicine
  • Environmental and molecular mutagenesis
  • 1 December 2011
  • As part of the Stage 3 of the Pig-a international trial, we evaluated 7,12-dimethylbenz(a)anthracene (DMBA) for induction of Pig-a gene mutation using a 28-day repeat dose study design inContinue Reading
  • Kamala Pant, Shannon Wilson Bruce, +8 authors Rohan Kulkarni
  • Biology, Medicine
  • Environmental and molecular mutagenesis
  • 1 July 2016
  • Bacterial mutation assays are conducted routinely as part of the safety assessment of new chemicals. The OECD Test Guideline (TG) 471 describes the conduct of the standard agar plate Ames assay,Continue Reading
  • Kamala Pant, Jamie E. Sly, Shannon Wilson Bruce, Cleo D. Leung, Richard H. C. San
  • Biology, Medicine
  • Mutation research
  • 1 July 2008
  • The Syrian hamster embryo (SHE) cell transformation assay has traditionally been conducted with a feeder layer of X-ray irradiated cells to provide growth support to the target cells seeded in lowContinue Reading
    The SHE cell transformation assay has traditionally been conducted with a feeder layer of X-ray irradiated cells to provide growth support to the target cells seeded in low numbers. The need for anContinue Reading