Jamie E. Sly

Publications11
h-index7
Citations162
Highly Influential Citations10
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Recommended protocol for the Syrian hamster embryo (SHE) cell transformation assay.
The Syrian hamster embryo (SHE) cell transformation assay (CTA) is a short-term in vitro assay recommended as an alternative method for testing the carcinogenic potential of chemicals. SHE cells are… Expand
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Assessment of genotoxicity induced by 7,12‐dimethylbenz(a)anthracene or diethylnitrosamine in the Pig‐a, micronucleus and Comet assays integrated into 28‐day repeat dose studies
As part of the Stage 3 of the Pig‐a international trial, we evaluated 7,12‐dimethylbenz(a)anthracene (DMBA) for induction of Pig‐a gene mutation using a 28‐day repeat dose study design in… Expand
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Photo catalogue for the classification of cell colonies in the Syrian hamster embryo (SHE) cell transformation assay at pH 6.7.
This catalogue is a display of Syrian hamster embryo (SHE) cell colony photos representative of the cell transformation assay (CTA) carried out at pH 6.7. It is intended as a visual aid for the… Expand
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Prevalidation study of the Syrian hamster embryo (SHE) cell transformation assay at pH 6.7 for assessment of carcinogenic potential of chemicals.
The Syrian hamster embryo (SHE) cell transformation assay (CTA) is an important in vitro method that is highly predictive of rodent carcinogenicity. It is a key method for reducing animal usage for… Expand
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An international validation study of a Bhas 42 cell transformation assay for the prediction of chemical carcinogenicity.
The Bhas 42 cell transformation assay is a sensitive short-term system for predicting chemical carcinogenicity. Bhas 42 cells were established from BALB/c 3T3 cells by the transfection of v-Ha-ras… Expand
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Syrian hamster embryo (SHE) cell transformation assay with conditioned media (without X-ray irradiated feeder layer) using 2,4-diaminotoluene, 2,6-diaminotoluene and chloral hydrate.
The Syrian hamster embryo (SHE) cell transformation assay has traditionally been conducted with a feeder layer of X-ray irradiated cells to provide growth support to the target cells seeded in low… Expand
  • 12
Syrian Hamster Embryo (SHE) cell transformation assay with and without X-ray irradiation of feeder cells using Di(2-ethylhexyl)phthalate (DEHP) and N-nitroso-N-methylnitroguanidine (MNNG).
The SHE cell transformation assay has traditionally been conducted with a feeder layer of X-ray irradiated cells to provide growth support to the target cells seeded in low numbers. The need for an… Expand
  • 7
Combination comet/micronucleus assay validation performed by BioReliance under the JaCVAM initiative.
In the international validation study of the in vivo rat alkaline comet assay (comet assay), the Japanese Center for the Validation of Alternative Methods (JaCVAM) provided three coded chemicals to… Expand
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Bacterial mutagenicity assays: Vehicle and positive control results from the standard Ames assay, the 6‐ and 24‐well miniaturized plate incorporation assays and the Ames II™ assay
Bacterial mutation assays are conducted routinely as part of the safety assessment of new chemicals. The OECD Test Guideline (TG) 471 describes the conduct of the standard agar plate Ames assay,… Expand
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Comet assay in rat lung, bronchoalveolar lavage (BAL) cells and nasal tissue, site of contact tissues in inhalation studies