Jameson Beach

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Exposure to bacterial endotoxins has long been known to stimulate the release of anterior pituitary hormones; administration of endotoxin was at one time a common clinical test of anterior pituitary function. Endotoxin is a potent stimulus for production of the endogenous pyrogenic protein, interleukin-1 (IL-1), by macrophages and monocytes. The possibility(More)
Delayed or direct pseudopregnancies were induced by electrical stimulation of the cervix at 1400 h on diestrus day 2 (D-2) or on estrus, respectively. Blood samples for measurement of prolactin and LH by radioimmunoassay were collected by rapid decapitation at 5, 15, 30, 45 or 60 min after cervical stimulation or thereafter at 3-h intervals throughout the(More)
Previous studies demonstrated a direct action of interleukin-1 (IL-1) on release of hormones from rat anterior pituitary cells in monolayer culture. To rule out any possibility of a paracrine effect from the elevated hormones in the static monolayer system, and to examine further the dynamics of hormone release elicited by IL-1, studies were conducted with(More)
A rat prolactin solid-phase radioimmunoassay has been developed that uses 96-well microtiter plates with removable wells to which the antibody is firmly adsorbed, resulting in a solid-phase antibody. Antigen as either reference or unknown competes with radioactivity labeled antigen for binding sites on the solid-phase antibody. After immunoreaction, free(More)
OBJECTIVE Amnesic mild cognitive impairment (MCIa) is often characterized as an early stage of Alzheimer's dementia (AD). The latency of the P2, an electroencephalographic component of the flash visual evoked potential (FVEP), is significantly longer in those with AD or MCIa when compared with controls. The present investigation examined the diagnostic(More)
Pituitary-testicular function was examined in adult male rats with aminonucleoside-induced nephrotic syndrome as a model for similar disease in humans. Nephrotic rats developed androgen deficiency, as manifested by decreased prostate and seminal vesicle weights, lower serum total and free testosterone levels, and reduced testosterone release from testes(More)
Seventy-nine homozygous SS patients were randomly assigned to control or oral prophylactic urea treatment in a double-blind trial designed to determine whether prophylactic oral urea, in low doses, prevents sickle cell crises. The average follow-up time for these patients was 13.7 months and 33 patients were diagnosed as having one or more crises during the(More)
We investigated whether the inhibition of prolactin secretion from pituitary cells by carbachol, a cholinergic agonist resistant to hydrolysis by cholinesterases, would be a useful bioassay to explore an important nonneuronal action of antimuscarinic agents. Carbachol inhibited prolactin secretion from cultured rat anterior pituitary cells in a(More)
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